Pediculicidal Activity of Foeniculum vulgare Essential Oil in Treatment of Pediculus capitis as a Public Health Problem.

Pub Date : 2022-03-01 DOI:10.18502/jad.v16i1.11193

Elham Jahanifard, Hoda Ghofleh-Maramazi, Mona Sharififard, Mohammad Mahmoodi Sourestani, Amal Saki-Malehi, Elham Maraghi, Sima Rasaei

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引用次数: 1

Abstract

Background: Pediculosis, caused by Pediculus spp is an important public health problem in urban and rural areas around the world. Natural compounds such as plant essential oils (EOs) have been suggested as a potential alternative for insect pest control recently. The purpose of this study was to investigate the toxicity of Foeniculum vulgare essential oil against the head louse, Pediculus capitis under laboratory conditions.

Methods: Fennel essential oil components were analyzed using GC-mass apparatus. Immersion and contact filter paper bioassays were used to evaluate fennel essential oil toxicity at the two-fold concentrations of 2.5, 5, 10, 20, and 40% against nit and nymph/adult stages of the head louse.

Results: Trans-anethole, α-Thujone, and limonene, which consisted of 76.08%, 10.37%, and 5.34% were the most components of fennel oil respectively. The LC₅₀ values for the adult /nymphs were 11.5, 6.4, 3.9, 3.1 and 2.5% and LC₉₉ values were 29.5, 15.2, 12.8, 10.8, and 7.4% at 10, 20, 30, 45 and 60 minutes after exposure respectively. The lethal times (LT₅₀) for adults/nymphs were 5.2, 8.1, 9.5, 20.5, and 45.8 minutes and LT₉₉ were 138.6, 91.3, 23.8, 21.7, and 13.9 minutes in the concentrations of 2.5, 5, 10, 20 and 40%, respectively. LC₅₀ and LC₉₉ values were 2.32% and 7.36% after 5 days for the eggs.

Conclusion: Fennel essential oil at the concentration of 15% after 20min is suggested to develop as an appropriate formulation to evaluate in clinical trials.

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普通小茴香精油在治疗公共卫生问题中的杀蒂作用。

背景:由马先蒿(Pediculus spp)引起的弓根病(Pediculosis)是世界范围内城市和农村的一个重要公共卫生问题。近年来，植物精油等天然化合物被认为是防治害虫的潜在替代品。在实验室条件下，研究了寻常小茴香精油对头虱的毒性作用。方法:采用气相色谱质谱仪对茴香精油成分进行分析。采用浸没和接触滤纸生物测定法，评价茴香精油在2.5、5、10、20和40%两倍浓度下对头虱尼虫期和若虫/成虫期的毒性。结果:茴香油的主要成分为反式茴香脑、α-图琼酮和柠檬烯，其含量分别为76.08%、10.37%和5.34%。暴露后10、20、30、45和60 min，成虫/若虫LC50分别为11.5、6.4、3.9、3.1和2.5%，LC99分别为29.5、15.2、12.8、10.8和7.4%。在2.5%、5%、10%、20%和40%浓度下，成虫/稚虫的致死时间(LT50)分别为5.2、8.1、9.5、20.5和45.8 min, LT99分别为138.6、91.3、23.8、21.7和13.9 min。5 d后LC50和LC99分别为2.32%和7.36%。结论:茴香精油在20min后浓度为15%，建议作为合适的配方进行临床试验评价。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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