Debasish Mishra, G. Ray, Smita Mahapatra, Pankaj Parida
{"title":"ABO typing error resolution and transfusion support in a case of an acute leukemia patient showing loss of antigen expression","authors":"Debasish Mishra, G. Ray, Smita Mahapatra, Pankaj Parida","doi":"10.4103/ctm.ctm_28_19","DOIUrl":null,"url":null,"abstract":"ABO and RhD typing is an essential step before the transfusion of blood components to a patient. ABO blood group system is a significant group, which causes hemolytic transfusion reaction destroying donor red blood cells. Hence, ABO typing error should be resolved before transfusion. Especially acute leukemia patients, there is a loss of A, B, and H antigens. In this group of patients, no reaction was seen in Cell typing/forward grouping typing. An adsorption-elution study is required to support the correct blood type. Response with anti-A1, anti-AB, and anti-H in red cell typing and saliva testing is necessary to distinguish between different weak A subgroups. We presented a case of loss of A antigens and transfusion support to a leukemia patient for initiation of chemotherapy.","PeriodicalId":9428,"journal":{"name":"Cancer Translational Medicine","volume":"51 1","pages":"80 - 82"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Translational Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ctm.ctm_28_19","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
ABO and RhD typing is an essential step before the transfusion of blood components to a patient. ABO blood group system is a significant group, which causes hemolytic transfusion reaction destroying donor red blood cells. Hence, ABO typing error should be resolved before transfusion. Especially acute leukemia patients, there is a loss of A, B, and H antigens. In this group of patients, no reaction was seen in Cell typing/forward grouping typing. An adsorption-elution study is required to support the correct blood type. Response with anti-A1, anti-AB, and anti-H in red cell typing and saliva testing is necessary to distinguish between different weak A subgroups. We presented a case of loss of A antigens and transfusion support to a leukemia patient for initiation of chemotherapy.