The efficacy of treatment for demodex blepharitis with senile entropion of lower eyelid

Abstract

Objective To evaluate the efficacy of treatment for demodex blepharitis with senile entropion of lower eyelid. Methods Prospective randomized controlled study. Total of 104 eyes of 52 cases diagnosed as demodex blepharitis and senile entropion of lower eyelid in this hospital from Jan. 2018 to Dec. 2018. were sellected All patients were randomly divided into two groups. The trial group, 62 eyes of 31 cases, applied with tea tree oil eye sticker twice a day, tobramycin and dexamethasone ointment on palpebral margin once per night for 4 weeks consecutively, and then received modified plication of lower eyelid retractor for entropion. And the control group, 42 eyes of 21 cases, received surgery only without preopeative medication. Results Before treatment, the difference in symptom scores was not statistically significant between two groups (Z=-0.095, P=0.924). The symptom scores of trail group at 1 month after surgery were less than those of control group (Z=-3.039, P=0.002). The score of trial group decreased from 5.16±1.39 to 0.94±0.85. The score of control group decreased from 5.24±1.48 to 1.86± 1.06. The difference in the recurrence rate was not statistically significant between two groups (χ2=1.51, P=0.22). Conclusion Tobramycin and dexamethasone ointment, tea tree oil eye sticker combined with surgery for the treatment of demodex blepharitis with senile entropion of lower eyelid can improve the symptoms. Key words: Blepharitis, demodex; Entropion, lower eyelid, senile; Oil, tea tree; Ointment, tobramycin, dexamethasone; Plication, retractor, lower eyelid, modified