The Nomenclature of Properdin Factor B Allotypes

G. Mauff , G. Hauptmann, H.W. Hitzeroth , F. Gauchel, R. Scherz
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引用次数: 56

Abstract

In a comparative study the presently known eleven allotypes of properdin factor B (Bf) were examined. Bf polymorphism consists of the two common alleles F and S, the two less common alleles F 1 and S 1 and seven further rare alleles. A variant designation has been proposed according to their relative electrophoretic mobility in comparison to the migration difference between the S and F 1 band. Three rare variant alleles were redesignated : F 1.55, SO.45 and SO.7, which previously had been described as F 1.6, S 0.8 and S 1, respectively. Conversion studies did neither reveal variant mobility in the Bb nor in the Ba fragment of factor B in three of the rare alleles. This finding confirms the earlier report on one of the variants, possibly suggesting the existence of a so far unknown third clearing fragment.

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适当因子B同种型的命名
在一项比较研究中,对目前已知的11种适当因子B (Bf)的同种异体进行了检查。Bf多态性由2个常见等位基因F和S、2个不常见等位基因f1和s1以及另外7个罕见等位基因组成。根据它们的相对电泳迁移率,比较S和f1波段之间的迁移差异,提出了一种变体名称。3个罕见变异等位基因分别为f1.55、SO.45和SO.7,之前分别被描述为f1.6、s0.8和s1。转换研究没有发现三个罕见等位基因中因子B的Bb片段和Ba片段的变异流动性。这一发现证实了早先关于其中一个变体的报告,可能表明存在迄今未知的第三个清除碎片。
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