Analysis of Drug Utilization in Patients with Psoriasis: A Real-World Retrospective Study Among the Italian Population.

IF 5.2 Q1 DERMATOLOGY Psoriasis (Auckland, N.Z.) Pub Date : 2023-01-01 DOI:10.2147/PTT.S396003
Valentina Perrone, Serena Losi, Silvia Sabatino, Maurizio Mezzetti, Melania Dovizio, Diego Sangiorgi, Luca Degli Esposti
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引用次数: 1

Abstract

Purpose: An Italian real-world retrospective study was conducted in patients with psoriasis (PSO) to evaluate their characteristics, treatment patterns, and biological/targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD) drug utilization.

Patients and methods: The retrospective analysis was carried out on real-world data collected from administrative databases of selected Italian health-departments; the dataset covered approximately 22% of the Italian population. PSO patients (identified by PSO hospitalization, and/or active exemption code and/or a topical anti-psoriatic medication prescription) were included. In prevalent patients identified during 2017-2018-2019-2020, baseline characteristics and treatment patterns were investigated. Moreover, b/tsDMARD drug utilization (focusing on persistence, monthly dosage, and mean duration between prescriptions) was evaluated in bionaïve patients included during 2015 and 2018.

Results: PSO was diagnosed in 241,552 (in 2017), 269,856 (in 2018), 293,905 (in 2019) and 301,639 (in 2020) patients. At the index date, almost 50% of patients had not received systemic medications, and 2% had received biological treatment. Among the b/tsDMARD-treated patients, a decrease in the use of tumour necrosis factor (TNF) inhibitors (60.0-36.4%, from 2017 to 2020) and an increase in the use of interleukin (IL) inhibitors (36.3-50.6%, from 2017 to 2020) were observed. In 2018, the persistence rates of TNF inhibitors and IL inhibitors in bionaïve patients ranged from 60.8-79.7% and 83.3-87.9%, respectively.

Conclusion: This real-world study of PSO drug utilization in Italy showed that a significant number of patients were not treated with systemic medications and only 2% of patients were treated with biologics. An increase in the use of IL inhibitors and a decrease in the prescription of TNF inhibitors over years were found. Patients treated with biologics were highly persistent with treatment. These data provide insight into routine clinical practice for PSO patients in Italy, suggesting that the optimization of treatment for PSO still represents an unmet medical need.

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银屑病患者药物使用分析:意大利人群的真实世界回顾性研究。
目的:意大利对银屑病(PSO)患者进行了一项现实世界回顾性研究,以评估其特征、治疗模式和生物/靶向合成疾病缓解抗风湿药物(b/tsDMARD)的药物使用情况。患者和方法:回顾性分析从选定的意大利卫生部门的行政数据库收集的真实数据;该数据集覆盖了大约22%的意大利人口。包括PSO患者(通过PSO住院,和/或有效豁免代码和/或局部抗银屑病药物处方来确定)。在2017-2018-2019-2020年期间确定的流行患者中,调查基线特征和治疗模式。此外,还评估了2015年至2018年bionaïve患者的b/tsDMARD药物利用情况(重点是持续时间、月剂量和处方间的平均持续时间)。结果:PSO确诊患者分别为241,552例(2017年)、269,856例(2018年)、293,905例(2019年)和301,639例(2020年)。在索引日期,近50%的患者未接受全身药物治疗,2%的患者接受了生物治疗。在b/ tsdmard治疗的患者中,肿瘤坏死因子(TNF)抑制剂的使用减少(从2017年到2020年,60.0-36.4%),白细胞介素(IL)抑制剂的使用增加(从2017年到2020年,36.3-50.6%)。2018年,bionaïve患者中TNF抑制剂和IL抑制剂的持续率分别为60.8-79.7%和83.3-87.9%。结论:意大利PSO药物利用的真实世界研究表明,大量患者没有接受全身药物治疗,只有2%的患者接受了生物制剂治疗。发现多年来IL抑制剂的使用增加,TNF抑制剂的处方减少。接受生物制剂治疗的患者高度坚持治疗。这些数据为意大利PSO患者的常规临床实践提供了见解,表明PSO治疗的优化仍然代表着未满足的医疗需求。
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