Altered neurotransmission in stress-induced depressive disorders: The underlying role of the amygdala in depression

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Neuropeptides Pub Date : 2023-04-01 DOI:10.1016/j.npep.2023.102322

Muhammad Asim , Huajie Wang , Abdul Waris

引用次数: 2

Abstract

Depression is the second leading cause of disability in the world population, for which currently available pharmacological therapies either have poor efficacy or have some adverse effects. Accumulating evidence from clinical and preclinical studies demonstrates that the amygdala is critically implicated in depressive disorders, though the underlying pathogenesis mechanism needs further investigation. In this literature review, we overviewed depression and the key role of Gamma-aminobutyric acid (GABA) and Glutamate neurotransmission in depression. Notably, we discussed a new cholecystokinin-dependent plastic changes mechanism under stress and a possible antidepressant response of cholecystokinin B receptor (CCKBR) antagonist. Moreover, we discussed the fundamental role of the amygdala in depression, to discuss and understand the pathophysiology of depression and the inclusive role of the amygdala in this devastating disorder.

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应激性抑郁症的神经传递改变:杏仁核在抑郁症中的潜在作用

抑郁症是世界人口残疾的第二大原因，目前可用的药物治疗要么疗效不佳，要么有一些不良反应。从临床和临床前研究中积累的证据表明，杏仁核与抑郁症密切相关，尽管其潜在的发病机制需要进一步研究。在这篇文献综述中，我们综述了抑郁症以及γ-氨基丁酸（GABA）和谷氨酸神经传递在抑郁症中的关键作用。值得注意的是，我们讨论了一种新的胆囊收缩素依赖性可塑性变化机制，以及胆囊收收缩素B受体（CCKBR）拮抗剂可能的抗抑郁反应。此外，我们还讨论了杏仁核在抑郁症中的基本作用，以讨论和理解抑郁症的病理生理学以及杏仁核在这种毁灭性疾病中的包容性作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.