Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis

IF 0.2 Q4 ENDOCRINOLOGY & METABOLISM Turkish Journal of Endocrinology and Metabolism Pub Date : 2020-01-01 DOI:10.25179/tjem.2020-77613
F. Esfahanian, Seyedeh Mahdieh Fotouk Kiaie, Roghayeh Ghelich, Z. Jadali
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Abstract

Introduction Hashimoto’s thyroiditis (HT) is characterized by diffuse lymphocytic infiltration of the thyroid gland and elevated level of antithyroidspecific autoantibodies. It is more prevalent among women, and its incidence has increased significantly in recent years (1). Although autoimmunity plays a pivotal role in Objective: A growing body of evidence shows a close relationship between oxidative stress and autoimmune conditions such as Hashimoto’s thyroiditis (HT). Among different markers of oxidative damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker and broadly used in research studies. Therefore, this study aimed to measure the level of 8-OHdG in the sera of patients with HT and healthy control (HC) participants. Material and Methods: In this study, patients were diagnosed with clinical (n=23) and subclinical (n=25) hypothyroidism because of HT and compared with 35 healthy participants. 8-OHdG was measured using enzyme-linked immunosorbent assay in patients and HC participants. Results: No significant difference was observed in the mean serum 8-OHdG levels between patients and HC participants. Conclusion: The results of this preliminary study do not support the fact that the serum level of 8-OHdG is a biomarker of oxidative stress in patients with HT. However, more detailed studies are needed to reveal the exact role of 8-OHdG in this autoimmune disease of the thyroid gland.
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桥本甲状腺炎患者血清8-OHdG水平
桥本甲状腺炎的特点是甲状腺弥漫性淋巴细胞浸润和抗甲状腺特异性自身抗体水平升高。它在女性中更为普遍,近年来发病率显著增加(1)。尽管自身免疫在其中起着关键作用目的:越来越多的证据表明氧化应激与自身免疫性疾病(如桥本甲状腺炎(HT))之间存在密切关系。在不同的氧化损伤标志物中,8-羟基脱氧鸟苷(8-OHdG)是一种普遍存在的标志物,被广泛应用于研究。因此,本研究旨在测量HT患者和健康对照(HC)参与者血清中8-OHdG的水平。材料与方法:在本研究中,患者被诊断为临床(n=23)和亚临床(n=25)甲状腺功能减退症,并与35名健康参与者进行比较。采用酶联免疫吸附法测定患者和HC参与者的8-OHdG。结果:患者和HC参与者的平均血清8-OHdG水平无显著差异。结论:本初步研究结果不支持血清8-OHdG水平是HT患者氧化应激的生物标志物。然而,需要更详细的研究来揭示8-OHdG在这种甲状腺自身免疫性疾病中的确切作用。
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
7
审稿时长
8 weeks
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