Ethnic/Geographic Variation Of The Val34leu Polymorphism Of Coagulation Factor Xiii And Its Distribution In American Admixed Populations

Abstract

The Val34Leu polymorphism of coagulation Factor XIII gene shows a controversial relationship with homeostatic pathologies. Some studies have evidenced ethnic heterogeinity in its distribution but no patterns of genetic variability have been described so far; likewise, reports concerning admixed American populations remain scarce. We analyzed the diversity of inter and intragroup frequencies of the Leu34 using the estimators Dm and Gst', on data reported for populations classified into five genetic/geographic groups and also publish its frequencies in three Venezuelan populations, correlating these values with their levels of admixture. We confirm ethnic heterogeneity in the prevalence of Leu34 (Gst`=10.41%), yet important intra continental group variations must also be considered. Their frequency in American admixed populations varies as a function of their parental contributions. Clarifying the degree of variability of this polymorphism, together with other aspects of homeostasis, should lead to a better understanding of different geographical patterns of coagulation disorders manifestations.