B Cell Function in the Tumor Microenvironment.

IF 26.9 1区 医学 Q1 IMMUNOLOGY Annual review of immunology Pub Date : 2022-04-26 DOI:10.1146/annurev-immunol-101220-015603
Stephanie M Downs-Canner, Jeremy Meier, Benjamin G Vincent, Jonathan S Serody
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引用次数: 58

Abstract

The tumor microenvironment (TME) is a heterogeneous, complex organization composed of tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and innate and adaptive immune cells. Over the last decade, it has become increasingly clear that the immune cells in the TME play a critical role in controlling or promoting tumor growth. The function of T lymphocytes in this process has been well characterized. On the other hand, the function of B lymphocytes is less clear, although recent data from our group and others have strongly indicated a critical role for B cells in antitumor immunity. There are, however, a multitude of populations of B cells found within the TME, ranging from naive B cells all the way to terminally differentiated plasma cells and memory B cells. Here, we characterize the role of B cells in the TME in both animal models and patients, with an emphasis on dissecting how B cell heterogeneity contributes to the immune response to cancer.

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B细胞在肿瘤微环境中的功能。
肿瘤微环境(tumor microenvironment, TME)是一个由肿瘤细胞、间质细胞和内皮细胞组成的异质性复杂组织,其特征是肿瘤细胞与先天免疫细胞和适应性免疫细胞之间的串扰。在过去的十年中,越来越清楚的是,TME中的免疫细胞在控制或促进肿瘤生长方面起着关键作用。T淋巴细胞在这一过程中的作用已被很好地描述。另一方面,B淋巴细胞的功能不太清楚,尽管最近我们小组和其他人的数据强烈表明B细胞在抗肿瘤免疫中起关键作用。然而,在TME中发现了大量的B细胞群,从初始B细胞一直到终末分化的浆细胞和记忆B细胞。在这里,我们描述了B细胞在动物模型和患者的TME中的作用,重点是解剖B细胞异质性如何促进对癌症的免疫反应。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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