S. Agelaki, Krystallia Gourlia, M. Markaki, C. Papadaki, K. Rounis, E. Vorrias, Elena Prokova, E. Lagoudaki, A. Koutsopoulos, I. Tsamardinos, D. Mavroudis
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引用次数: 0
Abstract
: Platinum-based chemotherapy (CT) is a standard treatment for lung cancer, however a variety of chemoresistance mechanisms can impair its efficacy. MicroRNAs (miRNAs) represent potential biomarkers for the prediction of treatment efficacy in non-small cell lung cancer (NSCLC). We herein used a bioinformatics approach to identify differentially expressed (DE) miRNAs associated with response to platinum-based CT in NSCLC. We identified 6 miRNAs targeting signaling molecules participating in biological pathways involved in cancer and drug resistance. In summary, we developed a 6-miRNA signature that potentially predicts the response to cisplatin in NSCLC and warrants further validation in clinical samples.
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