Synthesis of 4-Alkylamino-2-Triazolylquinazolines

Svetlana Marija Goliškina, D. Cirule, Ē. Bizdēna, M. Turks
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Abstract

Abstract 5-Alkylamino derivatives of tetrazolo[1,5-a]quinazoline were obtained with high regioselectivity in the reaction of 5-azidotetrazolo[1,5-a]quinazoline (formally, 2,4-diazidoquinazoline) with long chain alkylamines. The obtained 5-aminoquinazoline derivatives were used in a copper catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction to obtain series of 4-(alkylamino-2-(1,2,3-triazol-1-yl)quinazolines.
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摘要采用长链烷基胺与5-叠氮四唑[1,5-a]喹唑啉(正式名称为2,4-二氮多喹唑啉)反应,得到了具有高区域选择性的5-烷基胺四唑[1,5-a]喹唑啉衍生物。将得到的5-氨基喹唑啉衍生物用于铜催化叠氮-炔1,3偶极环加成反应,得到一系列4-(烷基氨基-2-(1,2,3-三唑-1-基)喹唑啉。
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