A Simulation Based Screening on Different Coloring Agents used in Cosmetics and Pharmaceutical Industry for their Safety Profile

Abstract

Coloring agents are inseparable part of cosmetic, pharmaceutical Industry and food industry. A study conducted by Food Dyes Health Effects Assessment OEHHA in 2020 reported The percentage of US children and adolescents diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) increased from an estimated 6.1% to 10.2% in the past 20 years. Several studies revealed that Attention Deficit Hyperactivity Disorder could be caused by Artificial Food dyes In This study an attempt was made to perform the in silico safety analysis of Ferric ferrocyanide, caramel, Carmine, Betanine, Erythrosine,Tartrazine, Indigotine, Allura red, sunset yellow, Brillant blue, Curcumin, lawsone and Juglone coded in Python 2.7. The properties generated by the software were analyzed were molecular Weight (MW)Volume,TPSA, LogS, LogP, LogD, Caco-2 permeability, HIA, Protein binding, BBB permeability, skin sensitivity, carcinogenicity, eye irritation, respiratory toxicity, genotoxicity, non biodegrability and aquatic toxicity. The result of this study revealed a totally new dimension of the safety of these dyes and pigment which are widely used in the cosmetic, Food and Pharmaceutical Industry. Key words: in silico, prediction, Pigment, toxicity.