PREVALENCE OF FAT-SOLUBLE VITAMIN DEFICIENCIES ASSOCIATED WITH SEVERE ACUTE MALNUTRITION: A PROSPECTIVE OBSERVATIONAL STUDY

M. Shende, S. Kadam, M. Mokal, M. P. Balvir
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Abstract

Background: Severe acute malnutrition (SAM), among children below five years of age is global health problem contributing to childhood morbidity, mortality and remains a major embarrassment to optimal human capital development in India. Objectives: Study aim was to accesses fat soluble vitamins deficiencies among children with SAM and outcomes after treatments with F-75/F-100 plus vitamins mix. Methods: The study was prospective observational conducted in the nutritional rehabilitation center (NRC) at district general hospital for 6 months. Anthropometric measurements were taken to determine their nutritional status. Results: 100 patients of NRC were enrolled in the study. Sixty nine percent (69) patients had weight/height (WT/HT) Z score<−3 standard deviation (3 SD), 16 % with Z score<−2 and 15% of them had Z score<−4 malnutrition. Out of 100 children, 46% children were males, and 56% children were females. Vitamin E deficiencies (54%) were highly prevalent in hospitalized SAM groups, followed by 28% vitamin D and 18% were vitamin A deficient. Conclusion: Micronutrient deficiencies were highly prevalent with fat soluble vitamins and recovered on application of WHO protocols during hospitalization induced satisfactory fat-soluble vitamin status recovery significant (p<0.05).
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脂溶性维生素缺乏与严重急性营养不良相关的患病率:一项前瞻性观察研究
背景:5岁以下儿童严重急性营养不良(SAM)是造成儿童发病率和死亡率的全球性健康问题,并且仍然是印度最佳人力资本发展的一个主要难题。目的:研究目的是了解SAM儿童的脂溶性维生素缺乏症和使用F-75/F-100加维生素混合物治疗后的结果。方法:在区综合医院营养康复中心(NRC)进行为期6个月的前瞻性观察。采用人体测量来确定他们的营养状况。结果:100例NRC患者入组研究。69%(69)患者体重/身高(WT/HT) Z评分< - 3标准差(3sd), 16%的患者Z评分< - 2,15%的患者Z评分< - 4营养不良。在100名儿童中,46%为男性,56%为女性。住院的SAM组中维生素E缺乏症(54%)非常普遍,其次是维生素D缺乏症(28%)和维生素A缺乏症(18%)。结论:脂溶性维生素微量营养素缺乏症发生率高,住院期间应用WHO方案恢复后脂溶性维生素状态恢复满意(p<0.05)。
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