Effect of combination fluoxetine and exercise on prefrontal BDNF, anxiety-like behavior and fear extinction in a female rat model of post-traumatic stress disorder (PTSD): a comparison with male animals.

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES Behavioral and Brain Functions Pub Date : 2023-01-16 DOI:10.1186/s12993-023-00204-z
Sakineh Shafia, Farkhonde Nikkhah, Kobra Akhoundzadeh
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引用次数: 1

Abstract

Despite significant differences between men and women in the symptoms of PTSD and the response to therapeutic interventions, most PTSD studies have been done on male subjects. Continuing our previous study in male rats, this study aimed at better understanding the effect of a combination therapy of exercise with fluoxetine on female PTSD rats. The results were then compared with our past findings in male animals. Female adult Wistar rats subjected to PTSD were treated with moderate treadmill exercise or fluoxetine, or a combination of both. PTSD was induced by the single prolonged stress (SPS) model. Elevated plus-maze (EPM), serum and prefrontal BDNF, and fear extinctions were evaluated. The results showed that exercise plus fluoxetine decreased anxiety-like behavior, improved fear extinction, and increased BDNF changes in female rats. The effects of exercise alone were comparable with those of combination therapy except that combination therapy was more effective on OAT (open arm entry). The majority of results in female rats, except for those of prefrontal BDNF, 4th extinction, and OAT, were similar to those of male rats as shown in our previous study. According to our findings, exercise as a safe and cost-effective intervention can be considered as a complementary efficient option for PTSD treatment in both sexes. To achieve better treatment outcomes in PTSD patient, considering sex differences is recommended.

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氟西汀联合运动对创伤后应激障碍(PTSD)雌性模型大鼠前额叶BDNF、焦虑样行为和恐惧消退的影响:与雄性动物的比较
尽管男性和女性在PTSD的症状和对治疗干预的反应上存在显著差异,但大多数PTSD研究都是在男性受试者身上进行的。继续我们之前对雄性大鼠的研究,本研究旨在更好地了解运动与氟西汀联合治疗对雌性创伤后应激障碍大鼠的影响。然后将结果与我们过去在雄性动物中的发现进行比较。患有创伤后应激障碍的雌性成年Wistar大鼠接受中度跑步机运动或氟西汀治疗,或两者结合。单次延长应激(SPS)模型诱发PTSD。评估升高的正迷宫(EPM)、血清和前额叶BDNF以及恐惧消退。结果表明,运动加氟西汀减少了雌性大鼠的焦虑样行为,改善了恐惧消退,增加了BDNF的变化。单独运动的效果与联合治疗的效果相当,除了联合治疗对OAT(张开手臂进入)更有效。雌性大鼠除前额叶BDNF、第四灭绝、OAT外,大部分结果与我们前期研究中雄性大鼠的结果相似。根据我们的研究结果,运动作为一种安全且具有成本效益的干预措施,可以被认为是男女创伤后应激障碍治疗的补充有效选择。为使PTSD患者获得更好的治疗效果,建议考虑性别差异。
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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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