Cutaneous cryptococcal infection: Initial manifestation of acquired T-cell immunodeficiency due to malignant thymoma.

Q3 Medicine Current Medical Mycology Pub Date : 2022-06-01 DOI:10.18502/CMM.8.2.10334

Timothy McCann, Anar S Patel, Neha Patel D, Deepali B Sharath, Borna Mansouri, Cynthia Contreras

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引用次数: 1

Abstract

Background and purpose: Cryptococcosis is a known opportunistic infection. Thymomas are known to cause immune dysregulation. We describe an atypical case of cutaneous cryptococcosis in a patient with acquired T cell immunodeficiency that has been found to be secondary to a type B3 thymoma with progression to carcinoma.

Case report: A 63-year-old male presented with a chronic skin lesion confirmed as Cryptococcus neoformans on biopsy and an incidental mediastinal mass found during infectious work-up for the notable cluster of differentiation 4 (CD4)+ lymphopenia. This led to the diagnosis of a type B3 thymoma requiring resection. The cryptococcal lesion was treated successfully with azole therapy.

Conclusion: C. neoformans is an opportunistic infection rarely associated with isolated T cell immunodeficiency due to thymomas. A multidisciplinary approach and understanding of the pathogenicity of cryptococcus and the immunological effect of thymic dysfunction are paramount to diagnosis and treatment.

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皮肤隐球菌感染:恶性胸腺瘤引起的获得性t细胞免疫缺陷的初始表现。

背景与目的:隐球菌病是一种已知的机会性感染。众所周知，胸腺瘤会导致免疫失调。我们描述了一个非典型病例皮肤隐球菌病患者获得性T细胞免疫缺陷，已发现继发于B3型胸腺瘤进展为癌。病例报告:63岁男性，慢性皮肤病变，活检证实为新型隐球菌，在感染检查中发现偶发纵隔肿块，明显的CD4 +淋巴细胞减少。这导致B3型胸腺瘤的诊断需要切除。隐球菌病变用唑治疗成功。结论:新生C.是一种机会性感染，很少与胸腺瘤引起的分离T细胞免疫缺陷相关。多学科的方法和理解隐球菌的致病性和胸腺功能障碍的免疫学作用是诊断和治疗的重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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