Polyautoimmunity in systemic lupus erythematosus patients: New insights from a cross-sectional study

IF 4.7 Q2 IMMUNOLOGY Journal of Translational Autoimmunity Pub Date : 2023-01-01 DOI:10.1016/j.jtauto.2022.100187
Pedro Santos-Moreno , Julián Arias-Aponte , Gabriel-Santiago Rodríguez-Vargas , Paula Daniela Nieto-Zambrano , Laura Villarreal , Linda Ibatá , Susan Martinez , Jaime-Andrés Rubio-Rubio , Pedro Rodríguez , Adriana Rojas-Villarraga
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引用次数: 1

Abstract

Objective

To assess the frequency of polyautoimmunity (PolyA) in a cohort of Colombian patients with systemic lupus erythematosus (SLE) and to identify associated factors.

Methods

This is an analytical cross-sectional study in a specialized center., a comprehensive review of the medical records of SLE patients was performed from 2015 to 2020 in order to obtain demographic, clinical data, laboratory, and treatment information. Associations between PolyA, demographic, and characteristics of the disease were explored.

Results

A total of 463 patients were included in the analysis. The average age was 47.3 ± 15 years. Most of this population were female (87.4%), whom were diagnosed with SLE in a long-term SLE (10.6 ± 10.1 years). Out of the total patients, 34.7% were diagnosed with PolyA. Among the most frequent clinical criteria for SLICC, arthritis (65%), kidney impairment (39.5%), and alopecia (34.8%) were found. The most frequent SLE-associated PolyA were antiphospholipid syndrome (APS) and Sjögren's syndrome (SS) (16.63% and 10.58%, respectively). PolyA-associated factors were age, xerophthalmia, central nervous system occlusion, and deep vein thrombosis (DVT). In contrast, renal impairment was significantly less frequent in PolyA patients after multivariate analysis.

Conclusion

The results have showed associated factors with PolyA like age, xerophthalmia, central nervous system occlusion, and deep vein thrombosis in this cohort. On the other hand, lupus nephritis was less frequent in patients with PolyA. This study provides a spotlight of a specific SLE population as real-life evidence for a better characterization of PolyA in the future.

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系统性红斑狼疮患者的多重自身免疫:来自横断面研究的新见解
目的评估哥伦比亚系统性红斑狼疮(SLE)患者多重自身免疫(PolyA)的发生率,并确定相关因素。方法:本研究是在某专业中心进行的分析性横断面研究。,对2015年至2020年SLE患者的医疗记录进行了全面回顾,以获得人口统计学、临床数据、实验室和治疗信息。探讨了PolyA、人口统计学和疾病特征之间的关系。结果共纳入463例患者。平均年龄47.3±15岁。其中女性居多(87.4%),诊断为长期SLE(10.6±10.1年)。在所有患者中,34.7%被诊断为PolyA。SLICC最常见的临床诊断标准是关节炎(65%)、肾脏损害(39.5%)和脱发(34.8%)。最常见的与slea相关的PolyA是抗磷脂综合征(APS)和Sjögren综合征(SS)(分别为16.63%和10.58%)。与polya相关的因素有年龄、干眼症、中枢神经系统阻塞和深静脉血栓形成。相比之下,多因素分析后,PolyA患者肾脏损害的发生率明显较低。结论年龄、干眼症、中枢神经系统闭塞、深静脉血栓形成等因素与PolyA的发生有关。另一方面,狼疮肾炎在PolyA患者中较少发生。这项研究提供了一个特定SLE人群的焦点,作为未来更好地表征PolyA的现实证据。
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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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