The role of B cells in the development, progression, and treatment of lymphomas and solid tumors.

3区 医学 Q2 Medicine Advances in Immunology Pub Date : 2022-01-01 DOI:10.1016/bs.ai.2022.07.002
Jennifer K Lue, Stephanie Downs-Canner, Jayanta Chaudhuri
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Abstract

B cells are integral components of the mammalian immune response as they have the ability to generate antibodies against an almost infinite array of antigens. Over the past several decades, significant scientific progress has been made in understanding that this enormous B cell diversity contributes to pathogen clearance. However, our understanding of the humoral response to solid tumors and to tumor-specific antigens is unclear. In this review, we first discuss how B cells interact with other cells in the tumor microenvironment and influence the development and progression of various solid tumors. The ability of B lymphocytes to generate antibodies against a diverse repertoire of antigens and subsequently tailor the humoral immune response to specific pathogens relies on their ability to undergo genomic alterations during their development and differentiation. We will discuss key transforming events that lead to the development of B cell lymphomas. Overall, this review provides a foundation for innovative therapeutic interventions for both lymphoma and solid tumor malignancies.

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B细胞在淋巴瘤和实体瘤的发生、进展和治疗中的作用。
B细胞是哺乳动物免疫反应的组成部分,因为它们有能力产生针对几乎无限抗原的抗体。在过去的几十年里,在理解这种巨大的B细胞多样性有助于病原体清除方面取得了重大的科学进展。然而,我们对实体瘤和肿瘤特异性抗原的体液反应的了解尚不清楚。在这篇综述中,我们首先讨论了B细胞如何在肿瘤微环境中与其他细胞相互作用并影响各种实体瘤的发生和进展。B淋巴细胞产生针对多种抗原的抗体并随后针对特定病原体定制体液免疫反应的能力依赖于它们在发育和分化过程中经历基因组改变的能力。我们将讨论导致B细胞淋巴瘤发展的关键转化事件。总之,本综述为淋巴瘤和实体瘤恶性肿瘤的创新治疗干预提供了基础。
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来源期刊
Advances in Immunology
Advances in Immunology 医学-免疫学
CiteScore
9.90
自引率
0.00%
发文量
13
期刊介绍: Advances in Immunology has provided students and researchers with the latest information in Immunology for over 50 years. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. The articles stress fundamental concepts, but also evaluate the experimental approaches.
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