Could flavonoid aglycones prevent the absorption of flavonoid glycosides by inhibiting sodium-dependent glucose transporter-1 in the small intestine?

K. Sak
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Abstract

Flavonoids present a large group of natural polyphenols with numerous important health benefits for preventing and treating a diverse variety of pathological conditions. However, the actual therapeutic use of these phytochemicals is impeded by their low oral bioavailability. In this commentary article, an interesting paradox is presented: while the ingested flavonoid glycosides can be absorbed by means of sodium-dependent glucose transporters (SGLTs; SGLT1) located in the brush border membrane facing the lumen of the small intestine, certain flavonoid aglycones are able to inhibit these shuttle proteins. It is expected that avoiding the co-intake of such SGLT1 inhibitors concomitantly with flavonoid-rich foods might provide a new option for enhancing the oral bioavailability of flavonoids, thereby preventing the transport of unabsorbed compounds to the large intestine and conversion into catabolites by the colonic microbiota. Altogether, the administration of flavonoids in appropriate combinations is highlighted for getting the maximal health benefits from consuming these bioactive compounds.
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黄酮类苷元能否通过抑制小肠钠依赖性葡萄糖转运体-1来阻止黄酮类苷的吸收?
黄酮类化合物是一大类天然多酚类物质,对预防和治疗多种病理状况有许多重要的健康益处。然而,这些植物化学物质的实际治疗用途受到其低口服生物利用度的阻碍。在这篇评论文章中,提出了一个有趣的悖论:虽然摄入的类黄酮苷可以通过钠依赖性葡萄糖转运体(SGLTs;SGLT1)位于面向小肠管腔的刷状边界膜上,某些类黄酮苷元能够抑制这些穿梭蛋白。因此,避免与富含类黄酮的食物同时摄入此类SGLT1抑制剂可能为提高类黄酮的口服生物利用度提供新的选择,从而防止未吸收的化合物转运到大肠并被结肠微生物群转化为分解代谢物。总之,黄酮类化合物的适当组合的管理强调从消耗这些生物活性化合物中获得最大的健康益处。
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