Characteristics of Cellular Infiltration into Posterior Vitreous in Eyes with Uveitis on the Classification Basis Assessed Using Optical Coherence Tomography.

IF 1.8 Q3 OPHTHALMOLOGY Clinical ophthalmology Pub Date : 2023-01-01 DOI:10.2147/OPTH.S394441
Wataru Matsumiya, Sentaro Kusuhara, Noriyuki Sotani, Kyung Woo Kim, Ryuto Nishisho, Rei Sotani, Hisanori Imai, Akihito Uji, Makoto Nakamura
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引用次数: 2

Abstract

Purpose: To evaluate the characteristics of posterior vitreous cells in patients with uveitis on the classification basis using spectral domain optical coherence tomography (SD-OCT).

Methods: In this retrospective chart review, all eyes were classified into three groups: infectious uveitis (IFU, n=7), noninfectious granulomatous uveitis (NIGU, n=13), and noninfectious nongranulomatous uveitis (NINGU, n=13). We measured the size, number, and density of vitreous hyperreflective particles in the posterior vitreous area that was defined as the space between the vitreous top and the internal limiting membrane on OCT. The correlations between vitreous haze and vitreous particles were also evaluated.

Results: Thirty-three eyes from 23 patients with active posterior uveitis were included. IFU had significantly more particles than NIGU and NINGU (P=0.03 and P<0.001, respectively). The vitreous particle density was higher in IFU than in NIGU and NINGU (P=0.03 and P=0.003, respectively). The mean largest particle size was greater in IFU and NIGU than in NINGU (P=0.01 and P=0.03, respectively). The median vitreous haze of 2+ in IFU, 1+ in NIGU and NINGU showed no significant difference among three groups (P=0.21). Conversely, the correlation of the largest particle size with vitreous haze was significant at ρ= 0.44 (P=0.01).

Conclusion: SD-OCT may be useful for assessing ocular inflammation based on morphological characteristics of vitreous particles on the uveitis classification basis.

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光学相干断层扫描评价葡萄膜炎后玻璃体细胞浸润的分类特征。
目的:应用光谱域光学相干断层扫描(SD-OCT)对葡萄膜炎患者后玻璃体细胞的分类特征进行评价。方法:将所有眼睛分为感染性葡萄膜炎(IFU, n=7)、非感染性肉芽肿性葡萄膜炎(NIGU, n=13)和非感染性非肉芽肿性葡萄膜炎(NINGU, n=13) 3组。我们测量了玻璃体后区(定义为玻璃体顶部与内限定膜之间的空间)玻璃体高反射颗粒的大小、数量和密度,并评估了玻璃体雾霾与玻璃体颗粒之间的相关性。结果:纳入23例活动性后葡萄膜炎患者33只眼。IFU的颗粒含量显著高于NIGU和NINGU (P=0.03, PP=0.03, P=0.003)。IFU和NIGU的平均最大粒径大于NINGU (P=0.01和P=0.03)。IFU、NIGU、NINGU中位玻璃体雾度为2+,三组间差异无统计学意义(P=0.21)。相反,最大粒径与玻璃状雾霾的相关性显著,ρ= 0.44 (P=0.01)。结论:在葡萄膜炎分类的基础上,基于玻璃体颗粒的形态特征,SD-OCT可用于评估眼部炎症。
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来源期刊
Clinical ophthalmology
Clinical ophthalmology OPHTHALMOLOGY-
CiteScore
3.50
自引率
9.10%
发文量
499
审稿时长
16 weeks
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