Incompatibility Studies of Tamsulosin HCl using TGA, DSC and FT-IR

Abstract

The Benign Prostatic Hyperplasia is one of the common old age problem and alpha one adrenoreceptor blockers are commonly used for symptomatic relief. Tamsulosin HCl is selective alpha 1A adrenoreceptor blocker with better tolerability profile and once daily dosing advantage. The present study was under taken to establish the compatibility of Tamsulosin with a number of commonly used excipients by using thermo analytical technique viz Thermogravimetry (TG) and differential scanning calorimetry (DSC) used in formulation. The TG and DSC both results demonstrated that ethyl cellulose, Gelatin and lactose found to be incompatible with Tamsulosin and should be avoided for the pharmaceutical preparation.