An Association Study of ESR1-XbaI and PvuII Gene Polymorphism in Migraine Susceptibility in the Jammu Region.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY European Neurology Pub Date : 2023-01-01 DOI:10.1159/000527271

Sawan Kumar, Jyotdeep Kour Raina, Amrit Sudershan, Kanak Mahajan, Raman Jasrotia, Chinmoyee Maharana, Rakesh K Panjalia, Parvinder Kumar

{"title":"An Association Study of ESR1-XbaI and PvuII Gene Polymorphism in Migraine Susceptibility in the Jammu Region.","authors":"Sawan Kumar, Jyotdeep Kour Raina, Amrit Sudershan, Kanak Mahajan, Raman Jasrotia, Chinmoyee Maharana, Rakesh K Panjalia, Parvinder Kumar","doi":"10.1159/000527271","DOIUrl":null,"url":null,"abstract":"Introduction: Migraine is a neurovascular disorder and is clinically characterized by episodic attacks of mild to severe headaches. Due to the involvement of multiple environmental and genetic factors, it has become a much more complex neurological condition to understand. Apart from the environmental variables, a plethora of genes have been implicated, and one such example is ESR1. The present study was focused to find out the association of two important polymorphisms, namely, PvuII and XbaI of the ESR1 with migraine in the population of Jammu and Kashmir (UT).Methods: The PCR-RFLP genotyping method was utilized to detect PvuII and XbaI polymorphism, and the result was confirmed by statistical analysis.Results: Although we did not find a signification association of ESR-PvuII polymorphism with migraine susceptibility {OR: 1.14 at 95% CI [0.76-1.71] (p value 0.5)}, a strong association was found with the clinical subtype of migraine; migraine with aura (MA) {OR: 2.014 at 95% CI [1.069-3.792] (p value 0.028)}. Furthermore, a significant association of ESR-XbaI polymorphism was observed with migraine {OR: 1.908 at 95% CI [1.252-2.907] (p value 0.002) and its both clinical subtypes; migraine without aura (MO) {OR: 1.870 at 95% CI [1.186-2.950] (p value 0.006)} and MA {OR: 2.014 at 95% CI [1.069-3.792] (p value 0.028)}.Conclusion: In conclusion, ESR1-XbaI polymorphism is significantly associated with migraine risk including both subtypes (MA and MO) in the North Indian population of Jammu.","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":"86 1","pages":"55-62"},"PeriodicalIF":2.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000527271","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 2

Abstract

Introduction: Migraine is a neurovascular disorder and is clinically characterized by episodic attacks of mild to severe headaches. Due to the involvement of multiple environmental and genetic factors, it has become a much more complex neurological condition to understand. Apart from the environmental variables, a plethora of genes have been implicated, and one such example is ESR1. The present study was focused to find out the association of two important polymorphisms, namely, PvuII and XbaI of the ESR1 with migraine in the population of Jammu and Kashmir (UT).

Methods: The PCR-RFLP genotyping method was utilized to detect PvuII and XbaI polymorphism, and the result was confirmed by statistical analysis.

Results: Although we did not find a signification association of ESR-PvuII polymorphism with migraine susceptibility {OR: 1.14 at 95% CI [0.76-1.71] (p value 0.5)}, a strong association was found with the clinical subtype of migraine; migraine with aura (MA) {OR: 2.014 at 95% CI [1.069-3.792] (p value 0.028)}. Furthermore, a significant association of ESR-XbaI polymorphism was observed with migraine {OR: 1.908 at 95% CI [1.252-2.907] (p value 0.002) and its both clinical subtypes; migraine without aura (MO) {OR: 1.870 at 95% CI [1.186-2.950] (p value 0.006)} and MA {OR: 2.014 at 95% CI [1.069-3.792] (p value 0.028)}.

Conclusion: In conclusion, ESR1-XbaI polymorphism is significantly associated with migraine risk including both subtypes (MA and MO) in the North Indian population of Jammu.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

查谟地区ESR1-XbaI和PvuII基因多态性与偏头痛易感性的相关性研究

简介:偏头痛是一种神经血管疾病，临床表现为轻度至重度头痛的发作性发作。由于多种环境和遗传因素的参与，它已经成为一种更加复杂的神经系统疾病。除了环境变量，过多的基因也有牵连，其中一个例子就是ESR1。本研究的重点是找出两个重要的多态性，即PvuII和XbaI的ESR1与偏头痛在查谟和克什米尔(UT)的人群。方法:采用PCR-RFLP基因分型方法检测PvuII和XbaI多态性，并对结果进行统计分析。结果:虽然我们没有发现ESR-PvuII多态性与偏头痛易感性有显著相关性(OR: 1.14, 95% CI [0.76-1.71] (p值0.5))，但发现与偏头痛的临床亚型有很强的相关性;先兆偏头痛(MA) {OR: 2.014, 95% CI [1.069 ~ 3.792] (p值0.028)}。此外，ESR-XbaI多态性与偏头痛(OR: 1.908, 95% CI [1.252-2.907] (p值0.002)及其两种临床亚型显著相关;无先兆偏头痛(MO) {OR: 1.870, 95% CI [1.186 ~ 2.950] (p值0.006)}和MA {OR: 2.014, 95% CI [1.069 ~ 3.792] (p值0.028)}。结论:在查谟北部印度人群中，ESR1-XbaI多态性与偏头痛(包括MA和MO)的风险显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

European Neurology 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

审稿时长

4-8 weeks

期刊介绍： ''European Neurology'' publishes original papers, reviews and letters to the editor. Papers presented in this journal cover clinical aspects of diseases of the nervous system and muscles, as well as their neuropathological, biochemical, and electrophysiological basis. New diagnostic probes, pharmacological and surgical treatments are evaluated from clinical evidence and basic investigative studies. The journal also features original works and reviews on the history of neurology.