Correlation of Surfactant Protein-D (SP-D) Serum Levels with ARDS Severity and Mortality in Covid-19 Patients in Indonesia.

Q3 Medicine Acta medica academica Pub Date : 2022-04-01 DOI:10.5644/ama2006-124.366

Alexander Agustama, Anna Surgean Veterini, Arie Utariani

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引用次数: 6

Abstract

Objective: The purpose of this research was to investigate the correlation between serum levels of surfactant protein-D (SPD) with acute respiratory distress syndrome (ARDS) severity and mortality in COVID-19.

Materials and method: This was a prospective cohort research study that included 76 patients in the period from July to October 2020. SP-D serum levels were taken upon admission to the hospital, the diagnosis of ARDS and its grade were confirmed according to the WHO criteria, and then patients were observed for 28-day mortality.

Results: The mean SP-D serum levels from 76 patients were 39.33 ng/ml (SD±31.884 ng/ml). The statistical analysis showed that there was a significant correlation between SP-D serum levels and the severity of ARDS upon admission to the hospital (P=0.04, Spearman's rank correlation coefficient (rs)=0.26), but the correlation between serum levels of SP-D and mortality was not statistically significant (P=0.89; rs=-0.016).

Conclusion: SP-D serum levels had a significant but weak correlation with ARDS severity, but were not significant for mortality.

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印尼Covid-19患者血清表面活性蛋白d (SP-D)水平与ARDS严重程度和死亡率的相关性

目的:探讨血清表面活性蛋白d (SPD)水平与COVID-19患者急性呼吸窘迫综合征(ARDS)严重程度及病死率的相关性。材料和方法:这是一项前瞻性队列研究，包括76名患者，时间为2020年7月至10月。入院时检测血清SP-D水平，按照WHO标准确诊ARDS及其分级，观察患者28d死亡率。结果:76例患者血清SP-D水平平均为39.33 ng/ml (SD±31.884 ng/ml)。统计学分析显示，入院时血清SP-D水平与ARDS严重程度有显著相关(P=0.04, Spearman等级相关系数(rs)=0.26)，但血清SP-D水平与病死率的相关性无统计学意义(P=0.89;rs = -0.016)。结论:血清SP-D水平与ARDS严重程度有显著但微弱的相关性，与病死率无显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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