{"title":"Fish, Early-Life Stage (FELS) Toxicity Test (OECD TG 210)","authors":"Tg","doi":"10.1787/9789264304741-13-en","DOIUrl":null,"url":null,"abstract":"391. This test is widely used as a sub-chronic assay for non-endocrine disrupting (ED) chemicals, and can be used to predict concentrations causing chronic effects on growth and reproduction in fish. It was developed before concerns about endocrine disrupting chemicals (EDCs) arose and cannot be used to identify these chemicals. It exposes fish from immediately post-fertilisation to the larval free-feeding stage (28-60 days post-hatch [dph], depending on species). Permitted species include rainbow trout (Oncorhynchus mykiss), fathead minnow (Pimephales promelas), zebrafish (Danio rerio), medaka (Oryzias latipes), sheepshead minnow (Cyprinodon variegatus) and silverside (Menidia sp.). The main endpoints include mortality, time to hatching, hatching success, growth, morphological abnormalities and abnormal behaviour.","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"23 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"OECD Series on Testing and Assessment","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1787/9789264304741-13-en","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
391. This test is widely used as a sub-chronic assay for non-endocrine disrupting (ED) chemicals, and can be used to predict concentrations causing chronic effects on growth and reproduction in fish. It was developed before concerns about endocrine disrupting chemicals (EDCs) arose and cannot be used to identify these chemicals. It exposes fish from immediately post-fertilisation to the larval free-feeding stage (28-60 days post-hatch [dph], depending on species). Permitted species include rainbow trout (Oncorhynchus mykiss), fathead minnow (Pimephales promelas), zebrafish (Danio rerio), medaka (Oryzias latipes), sheepshead minnow (Cyprinodon variegatus) and silverside (Menidia sp.). The main endpoints include mortality, time to hatching, hatching success, growth, morphological abnormalities and abnormal behaviour.
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