Effect Of Aegle Marmelos Correa On Blood Glucose Level In Normal And Alloxan- Induced Diabetic Albino Rats

Abstract

The aim of the present study is to evaluate the action extract of Aegle marmelos correa on blood glucose level in normal and alloxan-induced diabetic albino rats. The aqueous extract (100mg/kg/d) was administered orally for four weeks to alloxaninduced diabetic rats. Blood glucose was estimated every week for four consecutive weeks. For evaluation of mechanism of action of test drug, glycogen estimation was done in liver, heart and skeletal muscle and effect on adrenaline-induced hyperglycemia was seen. The test drug significantly (p<0.01) reduced the rise in blood glucose induced by alloxan. The test drug produced significant (p<0.01) increase in liver glycogen and also significantly (p<0.01) reduced adrenaline-induced hyperglycaemia. No significant lowering of normal blood glucose was also found. Thus, the fruit of Aegle marmelos has significant antidiabetic activity.