[Benefits and harms of cannabis-based medicines from the viewpoint of patients with chronic pain and their physicians : A cohort study in three pain centers of the German federal state Saarland].

IF 1.1 4区 医学 Q3 ANESTHESIOLOGY Schmerz Pub Date : 2024-08-01 Epub Date: 2023-01-20 DOI:10.1007/s00482-022-00688-0
Claudia Böttge-Wolpers, Patric Bialas, Sven Gottschling, Stephanie Juckenhöfel, Dieter Konietzke, Albrecht Madlinger, Patrick Welsch, Winfried Häuser
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Abstract

Background: There are no studies available that have simultaneously assessed the benefits and harms of cannabis-based medicines from the viewpoint of patients and their physicians.

Methods: All chronic pain patients at three pain centres in the German federal state of Saarland who had received at least one prescription of cannabis-based medicines (CbMs) in the past from the study centre were included in a cross-sectional study from January 1 to December 31, 2021. Patients and their physicians completed a self-developed questionnaire separately.

Results: All 187 contacted patients participated in the study. Since the start of CbM therapy, 44.9% of patients reported to be much or very much, 43.3% to be moderately and 8.0% to be slightly improved overall. A total of 2.7% reported no change and 1.1% a moderate deterioration of overall wellbeing. From the patients' point of view, the symptoms most frequently reported to have substantially improved were sleep problems (36.4%), muscle tension (25.1%) and appetite problems (22.1%). The most frequent bothersome side effects were sweating (6.4%), concentration problems (4.2%) and nausea (4.1%). Physicians noted substantial pain relief in 60.7%, improvement of sleep in 65.7% and of mental well-being in 34.3%. A complete cessation of opioids was achieved in 64.7%, of anticonvulsants in 57.9% and of antidepressants in 60% of patients that had received these medications before the start of CbM therapy.

Conclusions: CbMs can contribute to a clinically relevant reduction in pain, sleep problems and muscle tension and can improve daily functioning in carefully selected and supervised patients with chronic pain. CbM can contribute to the reduction or complete cessation of other pain medications (antidepressants, anticonvulsants, opioids).

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[从慢性疼痛患者及其医生的角度看大麻药物的益处和害处:德国萨尔州三个疼痛中心的队列研究]。
背景:目前还没有研究从患者及其医生的角度同时评估大麻类药物的益处和害处:方法:在 2021 年 1 月 1 日至 12 月 31 日进行的一项横断面研究中,纳入了德国萨尔州三个疼痛中心的所有慢性疼痛患者,这些患者过去曾在研究中心接受过至少一次大麻类药物(CbMs)处方。患者及其医生分别填写了一份自行编制的调查问卷:所有187名联系过的患者都参与了研究。自开始接受 CbM 治疗以来,44.9% 的患者表示总体病情大为改善或非常改善,43.3% 的患者表示病情中度改善,8.0% 的患者表示病情轻微改善。共有 2.7% 的患者表示总体健康状况没有变化,1.1% 的患者表示总体健康状况中度恶化。从患者的角度来看,最常报告的得到实质性改善的症状是睡眠问题(36.4%)、肌肉紧张(25.1%)和食欲问题(22.1%)。最常见的副作用是出汗(6.4%)、注意力不集中(4.2%)和恶心(4.1%)。医生指出,60.7%的患者疼痛明显缓解,65.7%的患者睡眠得到改善,34.3%的患者精神状态良好。64.7%的患者完全停用了阿片类药物,57.9%的患者完全停用了抗惊厥药物,60%的患者在开始接受 CbM 治疗前停用了抗抑郁药物:结论:CbMs 在临床上有助于减轻慢性疼痛患者的疼痛、睡眠问题和肌肉紧张,并能改善他们的日常功能。CbM有助于减少或完全停用其他止痛药物(抗抑郁药、抗惊厥药、阿片类药物)。
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来源期刊
Schmerz
Schmerz 医学-临床神经学
CiteScore
2.00
自引率
20.00%
发文量
64
审稿时长
6-12 weeks
期刊介绍: Der Schmerz is an internationally recognized journal and addresses all scientists, practitioners and psychologists, dealing with the treatment of pain patients or working in pain research. The aim of the journal is to enhance the treatment of pain patients in the long run. Review articles provide an overview on selected topics and offer the reader a summary of current findings from all fields of pain research, pain management and pain symptom management. Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange. Case reports feature interesting cases and aim at optimizing diagnostic and therapeutic strategies. Review articles under the rubric ''Continuing Medical Education'' present verified results of scientific research and their integration into daily practice.
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