{"title":"Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer","authors":"Z. Mojtahedi, Somayeh Rezaeifard, Z. Faghih","doi":"10.17795/ACR-43883","DOIUrl":null,"url":null,"abstract":"Colon microbiota, as a complex and diverse population, has been shown to be either proor anti-tumorigenic, depending on its content. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which proor anti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance in microbiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggesting the contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"9 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Colorectal Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17795/ACR-43883","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Colon microbiota, as a complex and diverse population, has been shown to be either proor anti-tumorigenic, depending on its content. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which proor anti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance in microbiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggesting the contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.
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