Is the expression of placental epithelial and lymphoid markers associated with the perinatal outcomes in preeclampsia?

IF 1.2 4区医学 Q3 OBSTETRICS & GYNECOLOGY Ginekologia polska Pub Date : 2023-03-17 DOI:10.5603/GP.a2023.0027

Zeynep Bayramoğlu, Sibel Özler

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Abstract

Objectives: This study aimed to investigate the association of the epithelial and lymphoid immune markers with the adverse perinatal conditions such as early-onset preeclampsia (EOPE), fetal growth restriction (FGR) and intrauterine fetal death (IUFD) in preeclampsia in the placentae of preeclamptic patients.

Material and methods: A total of 60 pregnant patients were included in this study. The immunohistochemistry method was used to determine the expression levels of CD4, CD8, CD4 / CD8, CD68, P53, MDM2, CK18, CK19, E-cadherin, and β-catenin.

Results: In our study, the increase in E-cadherin expression in the preeclamptic fetal-maternal placental region was associated with EOPE and FGR development preeclampsia and the decrease in the expression of CD4 and CD8, which are involved in the local immunomodulation, was associated with IUFD.

Conclusions: Our data reveal that the increase in the expression of CK18, CK19, E-cadherin, and β-catenin and the decrease in CD4 and CD8 play a role in the pathogenesis of preeclampsia.

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胎盘上皮和淋巴标记物的表达与子痫前期围产儿结局有关吗?

目的:本研究旨在探讨上皮和淋巴免疫标记物与子痫前期患者胎盘早发性子痫前期(EOPE)、胎儿生长受限(FGR)和宫内死胎(IUFD)等不良围产期状况的关系。材料与方法:本研究共纳入60例孕妇。免疫组化法检测CD4、CD8、CD4 / CD8、CD68、P53、MDM2、CK18、CK19、E-cadherin、β-catenin的表达水平。结果:在我们的研究中，子痫前期胎母胎盘区E-cadherin表达升高与EOPE和FGR发生有关，参与局部免疫调节的CD4和CD8表达降低与IUFD有关。结论:我们的数据显示，CK18、CK19、E-cadherin、β-catenin的表达升高以及CD4、CD8的表达降低在子痫前期的发病过程中发挥了一定的作用。

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来源期刊

Ginekologia polska OBSTETRICS & GYNECOLOGY-

CiteScore

2.00

自引率

15.40%

发文量

317

审稿时长

4-8 weeks

期刊介绍： Ginekologia Polska’ is a monthly medical journal published in Polish and English language. ‘Ginekologia Polska’ will accept submissions relating to any aspect of gynaecology, obstetrics and areas directly related. ‘Ginekologia Polska’ publishes original contributions, comparative works, case studies, letters to the editor and many other categories of articles.