Diogo Magalhaes, Laurent Peyrin-Biroulet, Maria Manuela Estevinho, Silvio Danese, Fernando Magro
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引用次数: 3
Abstract
Background: Long-term management of inflammatory bowel diseases (IBD) is challenging and the identification of reliable predictors for treatment outcomes is an unmet need. Neutrophil-related biomarkers have been mainly studied in the feces, but blood analyses have inherent advantages.
Objective: To review the recent learnings on the ability of blood-based neutrophil-expressed biomarkers to predict treatment outcomes in IBD.
Design: Systematic scoping review.
Data sources and methods: We performed a literature search in Pubmed, EMBASE, SCOPUS, Web of Science, ScienceDirect, and Cochrane Central Register of Controlled Trials from inception until May 2022 according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. All human studies associating blood-based neutrophil-related compounds with the prediction of disease progression, complication onset, or treatment outcomes were included.
Results: From 1032 retrieved entries, 34 studies were selected, 32 published in 2013 or later. In all, 17 biomarkers from granules, cytoplasm, plasmatic membrane, and plasma were explored. In total, 1850 Crohn's disease (CD) and 1122 ulcerative colitis non-duplicated patients were included. The most mentioned biomarkers were nCD64, serum calprotectin (SC), oncostatin M (OSM), neutrophil elastase-generated calprotectin fragment (CPa9-HNE), and triggering receptor expressed on myeloid cells 1 (TREM1). Six biomarkers showed promising results: OSM, SC, eNAMPT, nCD64, TREM1, and CPa9-HNE. Variable positive signals were found for human neutrophil peptide 1-3, LL-37, S100A12, and neutrophil gelatinase-associated lipocalin. No predictive ability was found for the remaining markers. Sharing a neutrophil compartment did not indicate similar behavior.
Conclusion: Advances in the last decade began to unveil the untapped potential of the readily accessible blood neutrophil-expressed biomarkers, especially nCD64, TREM1, and CPa9-HNE. Current evidence suggests that future research should focus on well-defined subpopulations instead of a one-size-fits-all biomarker.
背景:炎症性肠病(IBD)的长期管理具有挑战性，确定可靠的预测治疗结果的需求尚未得到满足。中性粒细胞相关的生物标志物主要在粪便中进行研究，但血液分析具有固有的优势。目的:回顾近年来关于血液中性粒细胞表达的生物标志物预测IBD治疗结果的研究进展。设计:系统的范围审查。数据来源和方法:我们根据系统评价和meta分析指南的首选报告项目，从开始到2022年5月，在Pubmed、EMBASE、SCOPUS、Web of Science、ScienceDirect和Cochrane Central Register of Controlled Trials中进行了文献检索。所有将基于血液的中性粒细胞相关化合物与疾病进展、并发症发作或治疗结果的预测相关联的人类研究都被纳入其中。结果:从1032篇检索条目中，选择34篇研究，其中32篇发表于2013年及以后。总共从颗粒、细胞质、质膜和血浆中探索了17种生物标志物。共纳入1850例克罗恩病(CD)和1122例溃疡性结肠炎非重复患者。被提及最多的生物标志物是nCD64、血清钙保护蛋白(SC)、抑癌素M (OSM)、中性粒细胞弹性酶生成的钙保护蛋白片段(CPa9-HNE)和骨髓细胞上表达的触发受体1 (TREM1)。六种生物标志物显示出令人鼓舞的结果:OSM、SC、eNAMPT、nCD64、TREM1和CPa9-HNE。人中性粒细胞肽1-3、LL-37、S100A12和中性粒细胞明胶酶相关脂钙蛋白呈不同阳性信号。其余的标记没有预测能力。共用中性粒细胞隔室没有显示出类似的行为。结论:过去十年的进展开始揭示易于获得的血液中性粒细胞表达的生物标志物的未开发潜力，特别是nCD64, TREM1和CPa9-HNE。目前的证据表明，未来的研究应该把重点放在定义明确的亚种群上，而不是一个放之四海而皆准的生物标志物。注册:https://osf.io/kes9a。
期刊介绍：
Therapeutic Advances in Gastroenterology is an open access journal which delivers the highest quality peer-reviewed original research articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of gastrointestinal and hepatic disorders. The journal has a strong clinical and pharmacological focus and is aimed at an international audience of clinicians and researchers in gastroenterology and related disciplines, providing an online forum for rapid dissemination of recent research and perspectives in this area.
The editors welcome original research articles across all areas of gastroenterology and hepatology.
The journal publishes original research articles and review articles primarily. Original research manuscripts may include laboratory, animal or human/clinical studies – all phases. Letters to the Editor and Case Reports will also be considered.
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