Review on: Recent advances in mouth dissolving film

Pawan S. Avhad, Saurabh D. Nikam, Amit A. Chaudhari, S. Wagh, Meghana S. Rayjade, Prajwal Y. Gosavi
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Abstract

The fast dissolving orally disintegrating film are the designed to dissolve upon contact with wet surface or fluids like saliva, within a few seconds. Like a tablet, capsule, oral liquids there is no need of additional liquids like water. This is the most convenient dosage form for patients and also provides marketing advantages. In pediatric, geriatric and patient who have fear of choking orally disintegrating film is most convenient and popular dosage form. As the drug I directly absorb in blood through mucus membrane in mouth the degradation of drug in GIT and the first pass metabolism of drug is avoided which increase the arability of drug in plasma which increases therapeutic effect.This review gives information about all aspects from today’s point of view and gives idea about evaluation, formulation, manufacturing process of fast dissolving orally disintegrating film.
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口腔溶解膜的研究进展
这种快速溶解的口腔崩解膜被设计成在接触潮湿的表面或唾液等液体时在几秒钟内溶解。像片剂、胶囊、口服液一样,不需要额外的液体,比如水。这对患者来说是最方便的剂型,也提供了营销优势。口腔崩解片是儿童、老年人和有窒息恐惧的患者最方便、最流行的剂型。由于药物通过口腔粘膜直接吸收到血液中,避免了药物在胃肠道中的降解和药物的第一次代谢,增加了药物在血浆中的可用性,提高了治疗效果。本文从目前的角度对各方面进行了综述,并对快速溶解口腔崩解膜的评价、配方、制造工艺等方面提出了看法。
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