Clinical-epidemiological profile of confirmed cases of osteoarticular tuberculosis.

IF 1.8 Q3 INFECTIOUS DISEASES Journal of Bone and Joint Infection Pub Date : 2023-01-05 eCollection Date: 2023-01-01 DOI:10.5194/jbji-8-11-2023
Caroline Thomaz Panico, Priscila Rosalba Domingos de Oliveira, Vladimir Cordeiro de Carvalho, Angélica Makio Dos Anjos, Vanessa Ferreira Amorim de Melo, Ana Lucia Lei Munhoz Lima
{"title":"Clinical-epidemiological profile of confirmed cases of osteoarticular tuberculosis.","authors":"Caroline Thomaz Panico, Priscila Rosalba Domingos de Oliveira, Vladimir Cordeiro de Carvalho, Angélica Makio Dos Anjos, Vanessa Ferreira Amorim de Melo, Ana Lucia Lei Munhoz Lima","doi":"10.5194/jbji-8-11-2023","DOIUrl":null,"url":null,"abstract":"<p><p><b>Introduction</b>: tuberculosis (TB) remains a major cause of morbidity and mortality worldwide. The incidence of TB has increased since the 1980s. Given the increasing prevalence of TB worldwide, osteoarticular TB (OATB) is a significant health problem. <b>Methods</b>: retrospective study of a case series of hospitalized patients with confirmed OATB by culture or histopathological examination who were seen at a reference orthopedic hospital in São Paulo, Brazil, from 2014 to 2019. <b>Results</b>: thirty patients with confirmed bone and joint TB were seen from 2014 to 2019. The main sites of OATB were the spine (83.3 %) and the appendicular skeleton (26.7 %). Indication of surgical treatment was significantly related to the need for hospitalization ( <math><mrow><mi>p</mi> <mo>=</mo> <mn>0.009</mn></mrow> </math> ) and the increased length of hospital stay ( <math><mrow><mi>p</mi> <mo>=</mo> <mn>0.005</mn></mrow> </math> ). Presence of sequelae at the end of treatment was correlated with the presence of motor deficit at the time of OATB diagnosis ( <math><mrow><mi>p</mi> <mo>=</mo> <mn>0.035</mn></mrow> </math> ) as well as with initial presence of functional limitation ( <math><mrow><mi>p</mi> <mo>=</mo> <mn>0.025</mn></mrow> </math> ) and with high value of C-reactive protein at the end of treatment ( <math><mrow><mi>p</mi> <mo>=</mo> <mn>0.037</mn></mrow> </math> ). <b>Conclusions</b>: the delay in the onset of clinical and laboratory signs of cases of osteoarticular infections hinders the early diagnosis and treatment of the disease, resulting in major complications sometimes requiring surgical treatment and consequently leading to a prolonged hospital stay, evidence of high inflammatory activities, and the presence of neurological deficits.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850240/pdf/jbji-8-11.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bone and Joint Infection","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5194/jbji-8-11-2023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: tuberculosis (TB) remains a major cause of morbidity and mortality worldwide. The incidence of TB has increased since the 1980s. Given the increasing prevalence of TB worldwide, osteoarticular TB (OATB) is a significant health problem. Methods: retrospective study of a case series of hospitalized patients with confirmed OATB by culture or histopathological examination who were seen at a reference orthopedic hospital in São Paulo, Brazil, from 2014 to 2019. Results: thirty patients with confirmed bone and joint TB were seen from 2014 to 2019. The main sites of OATB were the spine (83.3 %) and the appendicular skeleton (26.7 %). Indication of surgical treatment was significantly related to the need for hospitalization ( p = 0.009 ) and the increased length of hospital stay ( p = 0.005 ). Presence of sequelae at the end of treatment was correlated with the presence of motor deficit at the time of OATB diagnosis ( p = 0.035 ) as well as with initial presence of functional limitation ( p = 0.025 ) and with high value of C-reactive protein at the end of treatment ( p = 0.037 ). Conclusions: the delay in the onset of clinical and laboratory signs of cases of osteoarticular infections hinders the early diagnosis and treatment of the disease, resulting in major complications sometimes requiring surgical treatment and consequently leading to a prolonged hospital stay, evidence of high inflammatory activities, and the presence of neurological deficits.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
骨关节结核确诊病例的临床流行病学概况。
导言:结核病(TB)仍然是全世界发病和死亡的主要原因。自 20 世纪 80 年代以来,结核病的发病率不断上升。鉴于结核病在全球的发病率不断上升,骨关节结核(OATB)是一个重要的健康问题。方法:对2014年至2019年期间在巴西圣保罗一家参考骨科医院就诊的经培养或组织病理学检查确诊为OATB的住院患者进行病例系列回顾性研究。结果:2014年至2019年期间,共接诊了30名确诊为骨与关节结核的患者。骨与关节结核的主要发病部位是脊柱(83.3%)和附属骨骼(26.7%)。手术治疗的指征与住院需求(P = 0.009)和住院时间(P = 0.005)的增加有显著关系。治疗结束时出现后遗症与确诊 OATB 时出现运动障碍相关(p = 0.035),也与最初出现功能受限相关(p = 0.025),还与治疗结束时 C 反应蛋白的高值相关(p = 0.037)。结论:骨关节感染病例的临床和实验室症状出现延迟阻碍了疾病的早期诊断和治疗,导致重大并发症,有时需要手术治疗,从而导致住院时间延长、高炎症活动证据和神经功能缺损的出现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
3.70
自引率
0.00%
发文量
29
审稿时长
12 weeks
期刊最新文献
Musculoskeletal manifestations of lower-extremity coccidioidomycosis: a case series Emergence of rifampicin-resistant staphylococci on the skin and nose of rifampicin-treated patients with an orthopaedic-device-related infection What is the agreement between principles and practice of antibiotic stewardship in the management of diabetic foot infection: an in-hospital quality control study. It is time for a unified definition of native vertebral osteomyelitis: a framework proposal. Ureaplasma urealyticum osteomyelitis of the greater trochanter in a patient with multiple sclerosis using ocrelizumab – a case report
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1