Observation on efficacy of pranoprofen eye drops in the treatment of Meibomian gland dysfunction

中华眼外伤职业眼病杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.2095-1477.2020.02.012

Gui-tong Ma, Wei Si, Xiao-yuan Yang

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Abstract

Objective To observe the efficacy of pranoprofen eye drops in the treatment of Meibomian gland dysfunction. Methods Clinical case-control study.Total of 62 eyes of 42 cases with Meibomian gland dysfunction in Huaxian People’s Hospital from May 2017 to Jun.2017 were randomly divided into two groups.There were 31 eyes of 21 cases in artificial tears group and 31 eyes of 21 cases in the pranoprofen eye drops group.The two groups were treated with artificial tears(4 times a day) or pranoprofen eye drops (3 times a day) for 1 month, respectively.The efficacy was observed at 1 month after treatment. Results The tear break-up time in the artificial tear group was ameliorated compared with that before treatment(t=2.211, P=0.033). The ocular symptoms, break-up time and corneal fluorescein staining in the pranoprofen group were significantly ameliorated compared with those before treatment(t=2.102, 2.401, 2.385, P=0.046, 0.018, 0.022). The difference of corneal fluorescein staining was not statistically significant between the two groups. Conclusion Non-steroidal anti-inflammatory eye drops therapy is effective for patients with Meibomian gland dysfunction. Key words: Dysfunction, Meibomian gland; Eye drops, pranoprofen; Treatment

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普萘洛芬滴眼液治疗睑板腺功能障碍的疗效观察

目的观察普萘洛芬滴眼液治疗睑板腺功能障碍的疗效。方法临床病例-对照研究。选取2017年5月至2017年6月在华县人民医院就诊的42例睑板腺功能障碍患者62只眼，随机分为两组。人工泪液组21例31眼，丙洛芬滴眼液组21例31眼。两组患者分别应用人工泪液(4次/ d)或普萘洛芬滴眼液(3次/ d)治疗，疗程1个月。治疗1个月后观察疗效。结果人工撕裂组泪液破裂时间较治疗前明显缩短(t=2.211, P=0.033)。与治疗前相比，普萘洛芬组患者眼部症状、破裂时间、角膜荧光素染色均有显著改善(t=2.102、2.401、2.385,P=0.046、0.018、0.022)。两组间角膜荧光素染色差异无统计学意义。结论非甾体类抗炎滴眼液治疗睑板腺功能障碍有较好的疗效。关键词:功能障碍;睑板腺;滴眼液、普萘洛芬;治疗

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