A history of ethanol intake accelerates the development of morphine analgesic tolerance: A protective potential for omega-3 fatty acids.

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES Behavioral neuroscience Pub Date : 2023-04-01 DOI:10.1037/bne0000542
S Mohammad Ahmadi-Soleimani, Hossein Azizi, Farimah Beheshti, Omid Azizi, Alireza Abbasi-Mazar
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Abstract

Adolescence is a critical life period during which significant neurodevelopmental changes occur within the central nervous system. Consistently, substance abuse in this stage has been found to induce persistent changes in brain responsiveness to future drug challenges. Nowadays, heavy episodic alcohol consumption during adolescence, also known as binge-drinking behavior, is a growing concern in modern societies. On the other hand, alcohol is well known to act as a gateway drug, that is, it promotes the individual's craving for consumption of other drugs of abuse. With this in mind, we aimed to assess whether adolescent ethanol exposure could alter the development of tolerance and dependence to morphine, as an available common opioid drug. Tail flick test was used to measure thermal nociceptive changes in adult male Wistar rats undergone ethanol/vehicle exposure during adolescence. Furthermore, morphine withdrawal syndrome was induced by naloxone injection, and behavioral signs were recorded for 20 min. It was found that adolescent ethanol intake facilitates morphine analgesic tolerance and decreases baseline latency; however, the severity of dependence is not significantly altered. Moreover, we found that 15 days of treatment with omega-3 fatty acids (O3) prevents the mentioned ethanol-induced changes suggesting a therapeutic potential for this compound. O3 supplementation, as an inexpensive and noninvasive method, may assist the clinicians to reverse the adverse effect of alcohol binge drinking on adolescents' brains and to reduce the vulnerability to drug exposure in adulthood. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

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乙醇摄入史加速了吗啡镇痛耐受性的发展:ω -3脂肪酸的保护潜力。
青春期是生命的关键时期,在此期间中枢神经系统发生了重大的神经发育变化。这一阶段的药物滥用一直被发现会导致大脑对未来药物挑战的反应性发生持续变化。如今,青春期大量间歇性饮酒,也被称为狂饮行为,是现代社会日益关注的问题。另一方面,众所周知,酒精是一种入门毒品,也就是说,它促进了个人对其他滥用药物的渴望。考虑到这一点,我们的目的是评估青少年酒精暴露是否会改变对吗啡的耐受性和依赖性的发展,吗啡是一种常见的阿片类药物。采用甩尾试验测量成年雄性Wistar大鼠在青春期酒精/交通工具暴露后的热伤害性变化。此外,纳洛酮注射诱导吗啡戒断综合征,并记录行为体征20 min。发现青少年乙醇摄入促进吗啡镇痛耐受性,降低基线潜伏期;然而,依赖的严重程度并没有显著改变。此外,我们发现用omega-3脂肪酸(O3)治疗15天可以防止上述乙醇引起的变化,这表明该化合物具有治疗潜力。O3补充作为一种廉价且无创的方法,可以帮助临床医生扭转酗酒对青少年大脑的不良影响,并减少成年后对药物暴露的脆弱性。(PsycInfo数据库记录(c) 2023 APA,版权所有)。
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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
期刊最新文献
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