Genotype Distribution and Antibiotic Susceptibility Pattern of Clinical Isolates of Group B Streptococcus in a Tertiary Care Hospital in Puducherry, South India.

IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Tropical Medicine Pub Date : 2023-01-01 DOI:10.1155/2023/9910380
A V Sangeetha, Sheela Devi, Anandhalakshmi Subramanian, Mary Daniel, Perumal Anandh
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引用次数: 1

Abstract

Background: Streptococcus agalactiae apart from being a colonizer in the genital region is also associated with several other invasive infections in all age groups. With the varied distribution of serotypes across different regions of the world, universal vaccination is also unattainable. However, in India, the knowledge of group B Streptococcus (GBS) genotype distribution is deficient. Thus, this study was initiated to add data on this aspect. Methodology. A cross-sectional study was conducted using isolates of group B Streptococcus from all clinical specimens. Along with that, the clinical specimen type and the antibiotic resistance profile of the isolates were correlated with the genotypes recognized through a multiplex PCR assay.

Results: Among the 86 isolates subjected to multiplex PCR for genotype identification, five genotypes were identified with genotype Ib as the predominant one (34.9%), followed by III (20.9%), II (16.3%), Ia (12.7%), and V (11.6%).

Conclusion: The results demonstrated a correlation of types Ib and III with vaginal colonization and type II with urine specimens in the current study. This preliminary study exhibited the distribution of common genotypes and their antibiotic resistance profiles in various GBS isolates. However, multiple studies across the country with larger sample sizes are needed to validate these findings.

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印度南部普杜切里一家三级医院B群链球菌临床分离株基因型分布和抗生素敏感性模式
背景:无乳链球菌除了是生殖区域的定植菌外,还与所有年龄组的其他几种侵袭性感染有关。由于血清型在世界不同区域的分布各不相同,普遍接种疫苗也是不可能实现的。然而,在印度,对B群链球菌(GBS)基因型分布的了解不足。因此,本研究旨在增加这方面的数据。方法。对所有临床标本中分离的B群链球菌进行了横断面研究。此外,分离株的临床标本类型和抗生素耐药谱与多重PCR检测识别的基因型相关。结果:86株分离菌株经多重PCR基因型鉴定,鉴定出5种基因型,以Ib基因型为主(34.9%),其次为III基因型(20.9%)、II基因型(16.3%)、Ia基因型(12.7%)、V基因型(11.6%)。结论:本研究结果表明Ib型和III型与阴道定植有关,II型与尿液标本有关。本初步研究显示了不同GBS分离株中常见基因型的分布及其抗生素耐药性谱。然而,需要在全国范围内进行更大样本量的多项研究来验证这些发现。
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来源期刊
Journal of Tropical Medicine
Journal of Tropical Medicine Immunology and Microbiology-Parasitology
CiteScore
3.90
自引率
4.50%
发文量
0
审稿时长
14 weeks
期刊介绍: Journal of Tropical Medicine is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of tropical diseases. Articles on the pathology, diagnosis, and treatment of tropical diseases, parasites and their hosts, epidemiology, and public health issues will be considered. Journal of Tropical Medicine aims to facilitate the communication of advances addressing global health and mortality relating to tropical diseases.
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