Neural suppression in odor recognition memory.

IF 2.8 4区 心理学 Q1 BEHAVIORAL SCIENCES Chemical Senses Pub Date : 2023-01-01 DOI:10.1093/chemse/bjad001
Tom Eek, Fredrik Lundin, Maria Larsson, Paul Hamilton, Charalampos Georgiopoulos
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Abstract

Abstract Little is known about the neural basis of lower- and higher-order olfactory functions such as odor memory, compared with other sensory systems. The aim of this study was to explore neural networks and correlates associated with 3 functions: passive smelling (PS), odor encoding (OE), and in particular odor recognition memory (ORM). Twenty-six healthy participants were examined using functional magnetic resonance imaging conducted across 3 sessions, one for each function. Independent component analysis revealed a difference between sessions where a distinct ORM component incorporating hippocampus and posterior cingulate showed delayed triggering dissociated from odor stimulation and recognition. By contrasting Hit for ORM (target odors correctly recognized as old) and a combination of PS and detected odors from OE, we found significantly lower activations in amygdala, piriform cortex, insula, thalamus, and the inferior parietal lobule. Region of interest analysis including anterior insula, posterior cingulate gyrus, dentate gyrus, left middle frontal gyrus, amygdala, and piriform cortex demonstrated that Hit were associated with lower activations compared with other memory responses. In summary, our findings suggest that successful recognition of familiar odors (odor familiarity) is associated with neural suppression in the abovementioned regions of interest. Additionally, network including the hippocampus and posterior cingulate is engaged in a postrecognition process. This process may be related to incidental encoding of less familiar and more novel odors (odor novelty) and should be subject for future research.

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气味识别记忆中的神经抑制。
与其他感觉系统相比,我们对低阶和高阶嗅觉功能(如气味记忆)的神经基础知之甚少。本研究的目的是探讨神经网络及其相关的3个功能:被动嗅觉(PS),气味编码(OE),特别是气味识别记忆(ORM)。26名健康参与者接受了功能性磁共振成像检查,分为三个阶段,每个阶段分别进行一次。独立成分分析显示,在不同的会话中,包含海马体和后扣带的ORM成分表现出延迟触发,与气味刺激和识别分离。通过对比Hit对ORM(正确识别为旧的目标气味)和PS和OE检测到的气味的组合,我们发现杏仁核、梨状皮质、脑岛、丘脑和下顶叶的激活明显降低。包括前岛、后扣带回、齿状回、左额中回、杏仁核和梨状皮质在内的兴趣区分析表明,与其他记忆反应相比,Hit的激活程度较低。总之,我们的研究结果表明,成功识别熟悉气味(气味熟悉度)与上述感兴趣区域的神经抑制有关。此外,包括海马体和后扣带在内的神经网络参与了后认知过程。这一过程可能与不太熟悉和更新颖的气味(气味新颖性)的偶然编码有关,应该是未来研究的主题。
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来源期刊
Chemical Senses
Chemical Senses 医学-行为科学
CiteScore
8.60
自引率
2.90%
发文量
25
审稿时长
1 months
期刊介绍: Chemical Senses publishes original research and review papers on all aspects of chemoreception in both humans and animals. An important part of the journal''s coverage is devoted to techniques and the development and application of new methods for investigating chemoreception and chemosensory structures.
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