Associations Between Thinner Retinal Neuronal Layers and Suboptimal Brain Structural Integrity in a Middle-Aged Cohort.

IF 3.1 Q1 OPHTHALMOLOGY Eye and Brain Pub Date : 2023-03-11 eCollection Date: 2023-01-01 DOI:10.2147/EB.S402510
Ashleigh Barrett-Young, Wickliffe C Abraham, Carol Y Cheung, Jesse Gale, Sean Hogan, David Ireland, Ross Keenan, Annchen R Knodt, Tracy R Melzer, Terrie E Moffitt, Sandhya Ramrakha, Yih Chung Tham, Graham A Wilson, Tien Yin Wong, Ahmad R Hariri, Richie Poulton
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Abstract

Purpose: The retina has potential as a biomarker of brain health and Alzheimer's disease (AD) because it is the only part of the central nervous system which can be easily imaged and has advantages over brain imaging technologies. Few studies have compared retinal and brain measurements in a middle-aged sample. The objective of our study was to investigate whether retinal neuronal measurements were associated with structural brain measurements in a middle-aged population-based cohort.

Participants and methods: Participants were members of the Dunedin Multidisciplinary Health and Development Study (n=1037; a longitudinal cohort followed from birth and at ages 3, 5, 7, 9, 11, 13, 15, 18, 21, 26, 32, 38, and most recently at age 45, when 94% of the living Study members participated). Retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness were measured by optical coherence tomography (OCT). Brain age gap estimate (brainAGE), cortical surface area, cortical thickness, subcortical grey matter volumes, white matter hyperintensities, were measured by magnetic resonance imaging (MRI).

Results: Participants with both MRI and OCT data were included in the analysis (RNFL n=828, female n=413 [49.9%], male n=415 [50.1%]; GC-IPL n=825, female n=413 [50.1%], male n=412 [49.9%]). Thinner retinal neuronal layers were associated with older brain age, smaller cortical surface area, thinner average cortex, smaller subcortical grey matter volumes, and increased volume of white matter hyperintensities.

Conclusion: These findings provide evidence that the retinal neuronal layers reflect differences in midlife structural brain integrity consistent with increased risk for later AD, supporting the proposition that the retina may be an early biomarker of brain health.

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中年队列中视网膜神经元层变薄与大脑结构完整性欠佳之间的关联
目的:视网膜具有作为大脑健康和阿尔茨海默病(AD)生物标志物的潜力,因为视网膜是中枢神经系统中唯一容易成像的部分,而且比大脑成像技术更具优势。很少有研究对中年样本的视网膜和大脑测量进行比较。我们的研究旨在调查中年人群中视网膜神经元测量值是否与大脑结构测量值相关:参与者是达尼丁多学科健康与发展研究(Dunedin Multidisciplinary Health and Development Study)的成员(n=1037;这是一个纵向队列,从出生开始,在3、5、7、9、11、13、15、18、21、26、32、38岁以及最近的45岁进行跟踪,94%的在世研究成员参与了这项研究)。视网膜神经纤维层(RNFL)和神经节细胞-内丛状层(GC-IPL)的厚度是通过光学相干断层扫描(OCT)测量的。磁共振成像(MRI)测量了脑年龄差距估计值(brainAGE)、皮质表面积、皮质厚度、皮质下灰质体积、白质高密度:同时获得核磁共振成像和光学视网膜成像数据的参与者均被纳入分析(RNFL n=828,女性 n=413 [49.9%],男性 n=415 [50.1%];GC-IPL n=825,女性 n=413 [50.1%],男性 n=412 [49.9%])。视网膜神经元层较薄与大脑年龄较大、皮质表面积较小、平均皮质较薄、皮质下灰质体积较小、白质高密度体积增加有关:这些发现提供了证据,表明视网膜神经元层反映了中年大脑结构完整性的差异,这与晚期注意力缺失症风险的增加一致,支持了视网膜可能是大脑健康早期生物标志物的观点。
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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
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