Evaluation of Antioxidant and Antinociceptive Properties of Methanolic Extract of Clerodendrum viscosum Vent.

Md. Mostafizur Rahman, N. N. Rumzhum, Kudrat-E-Khuda Zinna
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引用次数: 20

Abstract

The PDF for this article was updated on 18/11/2011. NN Rumzhum and K Zinna were added as authors on 18/11/2011. The methanolic extract of Clerodendrum viscosum vent. (Verbenaceae) was evaluated for in vitro antioxidant activity by determination of total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test and in vivo antinociceptive effect in acetic acid induced writhing model in swiss albino mice. The results revealed the presence of pronounced antioxidant property as compared with ascorbic acid used as standard and a dose-dependent (250 and 500 mg/kg) analgesic effect in Clerodendrum viscosum vent. The antioxidant and antinociceptive activities obtained seem to be in good accordance with the traditional uses of Clerodendrum viscosum . Key words : Clerodendrum viscosum; Verbenaceae; Antioxidant; Ascorbic acid; Antinociceptive; Swiss albino mice DOI: http://dx.doi.org/10.3329/sjps.v4i1.8873 SJPS 2011; 4(1): 74-78
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粘胶藤甲醇提取物抗氧化性和抗伤性的评价。
本文的PDF版本更新于2011年11月18日。NN Rumzhum和K Zinna于2011年11月18日添加为作者。粘枝藤的甲醇提取物。通过总抗氧化能力测定、一氧化氮清除能力测定和还原力测定以及醋酸致瑞士白化小鼠扭体模型的体内抗损伤作用来评价马鞭草科植物(Verbenaceae)的体外抗氧化活性。结果表明,与作为标准的抗坏血酸相比,粘胶酸具有明显的抗氧化性能,且其镇痛效果呈剂量依赖性(250和500 mg/kg)。所获得的抗氧化和抗伤活性似乎与粘胶的传统用途一致。关键词:粘枝;马鞭草科;抗氧化剂;抗坏血酸;Antinociceptive;瑞士白化小鼠DOI: http://dx.doi.org/10.3329/sjps.v4i1.8873 SJPS 2011;4 (1): 74 - 78
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