{"title":"G Proteins and Vesicle Trafficking","authors":"","doi":"10.1126/scisignal.1112001tw447","DOIUrl":null,"url":null,"abstract":"Attenuating a cellular signal is just as critical as inducing it. For example, regulator of G protein signaling (RGS) proteins modulate the signaling output from receptor-coupled heterotrimeric G proteins. Zheng et al. (see the Perspective by von Zastrow and Mostov) have identified what has been an elusive RGS for the Gαs class of G proteins. Named RGS-PX1, it also contains a membrane-interacting PhoX domain whose presence suggests a link between G protein signaling and vesicle trafficking in cells. B. Zheng, Y.-C. Ma, R. S. Ostrom, C. Lavoie, G. N. Gill, P. A. Insel, X.-Y. Huang, M. G. Farquhar, RGS-PX1, a GAP for Gαs and sorting nexin in vesicular trafficking. Science 294, 1939-1942 (2001). [Abstract] [Full Text] M. von Zastrow, K. Mostov, A new thread in an intricate web. Science 294, 1845-1847 (2001). [Full Text]","PeriodicalId":21619,"journal":{"name":"Science's STKE","volume":"970 1","pages":"tw447 - tw447"},"PeriodicalIF":0.0000,"publicationDate":"2001-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science's STKE","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1126/scisignal.1112001tw447","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Attenuating a cellular signal is just as critical as inducing it. For example, regulator of G protein signaling (RGS) proteins modulate the signaling output from receptor-coupled heterotrimeric G proteins. Zheng et al. (see the Perspective by von Zastrow and Mostov) have identified what has been an elusive RGS for the Gαs class of G proteins. Named RGS-PX1, it also contains a membrane-interacting PhoX domain whose presence suggests a link between G protein signaling and vesicle trafficking in cells. B. Zheng, Y.-C. Ma, R. S. Ostrom, C. Lavoie, G. N. Gill, P. A. Insel, X.-Y. Huang, M. G. Farquhar, RGS-PX1, a GAP for Gαs and sorting nexin in vesicular trafficking. Science 294, 1939-1942 (2001). [Abstract] [Full Text] M. von Zastrow, K. Mostov, A new thread in an intricate web. Science 294, 1845-1847 (2001). [Full Text]
衰减手机信号与诱导手机信号同样重要。例如，G蛋白信号调节蛋白(RGS)调节受体偶联异三聚体G蛋白的信号输出。Zheng等人(见von Zastrow和Mostov的观点)已经确定了Gαs类G蛋白的难以捉摸的RGS。它被命名为RGS-PX1，还包含一个与膜相互作用的PhoX结构域，其存在表明G蛋白信号传导与细胞中囊泡运输之间存在联系。郑B.， yyc .。马，R. S. Ostrom, C. Lavoie, G. N. Gill, P. A. Insel, x.y。黄明辉，黄明辉，黄明辉，RGS-PX1, g - α - s与分选连接蛋白在囊泡转运中的GAP。科学294,1939-1942(2001)。[摘要]M. von Zastrow, K. Mostov，复杂网络中的新线索。科学294,1845-1847(2001)。(全文)
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
