Synthesis, Characterization, Antibacterial and DNA Binding Studies of Mn (II) Complex of 3-(2-(2-Hydroxy-3- Methoxybenzylidene) Hydrazinyl) Quinoxalin-(1H)-One

Abstract

Mn (II) complex of the Schiff base (L), 3-(2-(2-hydroxy-3-methoxybenzylidene) hydrazinyl) quinoxalin-2(1H)-one (VHQO) was prepared and characterized by IR, UV-VIS, Mass, Elemental analysis, TGDTA, magnetic susceptibility and conductivity measurements. VHQO behaved as monobasic, tridentate ligand and formed 1:2 complex (ML2) with the metal ion (M) coordinating through ring nitrogen, azomethine nitrogen and phenolic oxygen. Thermal analysis of the complex indicated the absence of lattice and coordinated water. Based on the spectral and analytical data, octahedral geometry was assigned to the complex. Antibacterial activity of the complex against gram positive bacteria, Bacillus subtillis, Staphylococcus aureus, and gram negative bacteria, Escherichia coli, Proteus vulgaris, Pseudomonas aeroginosa , and Klebsiella pneumonia was studied. The interaction of the complex with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy and the intrinsic binding constant was calculated.