The effect of metal particles from a nickel refinery dump on alveolar macrophages. Part 2—environmental exposure of rabbits

Environmental Pollution Series A, Ecological and Biological Pub Date : 1986-01-01 DOI:10.1016/0143-1471(86)90077-2

E. Reichrtová, Ľ. Takáč, Z. Kováčiková

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引用次数: 5

Abstract

A group of New Zealand rabbits was exposed to environmental metal pollutants for 6 months via the respiratory route at the biomonitoring station near a nickel refinery dump. The count of alveolar macrophages (AM) and the lysosomal enzyme activities (acid phosphatase and β-glucuronidase) were significant reduction was found in the antibody-mediated rosette formation by AM in the exposed rabbits. In the in vitro system a dose-dependent inhibition of Fc receptor activity was detected in rabbit AM pretreated with a metal particle suspension at three concentrations (200, 400 and 600 μg ml⁻¹). The inhibitory effect of metal particle ingestion on the AM plasma membrane Fc receptor activity revealed the possible adverse effect of long-term exposure in a polluted area on the immune function of alveolar macrophages. Antibody-mediated rosette formation by AM may be a suitable assay for risk assessment of toxic pollutants in the ambient air.

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镍冶炼厂废弃金属颗粒对肺泡巨噬细胞的影响。第二部分:家兔的环境暴露

在镍冶炼厂垃圾场附近的生物监测站，一组新西兰兔通过呼吸途径暴露于环境金属污染物6个月。抗体介导的AM花环形成过程中，肺泡巨噬细胞(AM)计数和溶酶体酶活性(酸性磷酸酶和β-葡萄糖醛酸酶)显著降低。在体外系统中，用三种浓度(200,400和600 μg ml−1)的金属颗粒悬浮液预处理兔AM，检测到Fc受体活性的剂量依赖性抑制。金属颗粒摄入对AM质膜Fc受体活性的抑制作用揭示了长期暴露于污染区域可能对肺泡巨噬细胞免疫功能的不良影响。抗体介导的AM玫瑰结形成可能是一种适合于环境空气中有毒污染物风险评估的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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