Antidiabetic Properties of Aqueous Leaf and Stem Extracts of Andrographis paniculata on Alloxan Induced Diabetes in Wistar Rats

UMYU Journal of Microbiology Research (UJMR) Pub Date : 2022-06-30 DOI:10.47430/ujmr.2271.010

Z. H. Yusuf, V. M. Dan, Y. Magaji, G. B. Onwumere, E. Emmanuel

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Abstract

Diabetes mellitus is a disorder in which the body does not produce enough or respond normally to insulin, causing blood sugar (glucose) levels to be abnormally high. The aim of the study was to assess the effectiveness of Andrographis paniculata leaf and stem bark extracts in management of Alloxan induced diabetes Wistar rats. Fifty (50) Wistar rats were divided into eight groups, namely; group A (normal control), B, C, D, E, F, G and H (treatment groups). The study was conducted for four (4) weeks by measuring blood glucose levels in first four weeks. The result showed that the diabetic rats administered with 500mg/kg of aqueous leaf extract and 250mg/kg of stem bark extract were significantly lower than those of untreated control groups. However, the combined dose of 250mg/kg aqueous leaf and 250mg/kg stem extracts were not significantly different from untreated control group. Findings of the study have demonstrated that leaves and stem extract of A. paniculata exhibited significant blood sugar lowering property in Alloxan induced diabetic Wistar rats. Keywords: Andrographis paniculata; Blood sugar; Diabetes mellitus; Wistar rat

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穿心莲叶、茎水提物对四氧嘧啶诱导糖尿病Wistar大鼠的抗糖尿病作用

糖尿病是一种身体不能产生足够的胰岛素或对胰岛素反应不正常的疾病，导致血糖(葡萄糖)水平异常高。研究穿心莲叶及茎皮提取物对四氧嘧啶诱导的糖尿病大鼠的治疗作用。50只Wistar大鼠分为8组，分别为;A组(正常对照组)，B、C、D、E、F、G、H组(治疗组)。该研究通过测量前四周的血糖水平进行了四(4)周。结果表明，给予500mg/kg叶水提物和250mg/kg茎皮水提物的糖尿病大鼠的抗氧化能力显著低于未处理的对照组。250mg/kg水叶提取物和250mg/kg茎提取物的联合剂量与未处理对照组差异不显著。研究结果表明，对四氧嘧啶诱导的糖尿病大鼠，金针叶和金针茎提取物具有显著的降血糖作用。关键词:穿心莲;血糖;糖尿病;纯种老鼠

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UMYU Journal of Microbiology Research (UJMR)

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