Dual time point 18F-FDOPA PET as a tool for characterizing brain tumors

M. González-Forero, E. Prieto, I. Domínguez, C. Vigil, I. Peñuelas, J. Arbizu
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引用次数: 2

Abstract

18F-FDOPA is an amino acid analogue used to evaluate presynaptic dopaminergic activity, which has aroused great interest in neuro-oncology. We have evaluated five 18F-FDOPA PET studies of patients referred for study of parkinsonian syndrome. Two subjects had previously treated high- grade brain tumors, one nonspecific brain injury, and 2 subjects presented unexpected tumoral lesions. For all lesions SUVmax, time to SUVmax and tumor-to-normal grey matter SUVmax rate (T/N) were calculated, and 90 minutes 18F-FDOPA kinetics were analyzed. Tumor lesions corresponded to three malignant neurocytomas, one meningioma, one pineocytoma and one intrasinusal heman- gioma. Both malignant and benign tumors exhibited high uptake of 18F-FDOPA well above the normal cortex. However, the analysis of the curve uptake displayed characteristic patterns that facilitate the characterization of tumor lesions. A dual phase maximum uptake was observed, with an early 10 minutes uptake in malignant lesions, and a late 60 to 90 minutes uptake in benign or low grade lesions.

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双时间点18F-FDOPA PET作为表征脑肿瘤的工具
18F-FDOPA是一种用于评估突触前多巴胺能活性的氨基酸类似物,在神经肿瘤学领域引起了极大的兴趣。我们评估了5例帕金森综合征患者的18F-FDOPA PET研究。两名受试者先前治疗过高度脑肿瘤,一名非特异性脑损伤,2名受试者出现意外的肿瘤病变。对所有病变SUVmax,计算SUVmax时间和肿瘤与正常灰质SUVmax比率(T/N),分析90分钟18F-FDOPA动力学。肿瘤病变对应3例恶性神经细胞瘤、1例脑膜瘤、1例松果体细胞瘤和1例鼻内血管瘤。恶性和良性肿瘤均表现出18F-FDOPA的高摄取,远高于正常皮层。然而,对曲线摄取的分析显示了有助于肿瘤病变表征的特征模式。观察到双期最大摄取,恶性病变早10分钟摄取,良性或低级别病变晚60至90分钟摄取。
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