Photoacoustic imaging for microcirculation

IF 1.9 4区 医学 Q3 HEMATOLOGY Microcirculation Pub Date : 2022-07-06 DOI:10.1111/micc.12776
Shubham Mirg, Kevin L. Turner, Haoyang Chen, Patrick J. Drew, Sri-Rajasekhar Kothapalli
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引用次数: 5

Abstract

Microcirculation facilitates the blood-tissue exchange of nutrients and regulates blood perfusion. It is, therefore, essential in maintaining tissue health. Aberrations in microcirculation are potentially indicative of underlying cardiovascular and metabolic pathologies. Thus, quantitative information about it is of great clinical relevance. Photoacoustic imaging (PAI) is a capable technique that relies on the generation of imaging contrast via the absorption of light and can image at micron-scale resolution. PAI is especially desirable to map microvasculature as hemoglobin strongly absorbs light and can generate a photoacoustic signal. This paper reviews the current state of the art for imaging microvascular networks using photoacoustic imaging. We further describe how quantitative information about blood dynamics such as the total hemoglobin concentration, oxygen saturation, and blood flow rate is obtained using PAI. We also discuss its importance in understanding key pathophysiological processes in neurovascular, cardiovascular, ophthalmic, and cancer research fields. We then discuss the current challenges and limitations of PAI and the approaches that can help overcome these limitations. Finally, we provide the reader with an overview of future trends in the field of PAI for imaging microcirculation.

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用于微循环的光声成像
微循环促进血液组织交换营养物质,调节血液灌注。因此,它对维持组织健康是必不可少的。微循环异常可能表明潜在的心血管和代谢疾病。因此,关于它的定量信息具有重要的临床意义。光声成像(PAI)是一种依靠光吸收产生成像对比度并能以微米级分辨率成像的技术。PAI特别适合用于绘制微血管图,因为血红蛋白强烈吸收光并能产生光声信号。本文综述了利用光声成像技术对微血管网络进行成像的最新进展。我们进一步描述了如何定量信息的血液动力学,如总血红蛋白浓度,血氧饱和度和血流速率是如何使用PAI获得的。我们还讨论了它在理解神经血管、心血管、眼科和癌症研究领域的关键病理生理过程中的重要性。然后,我们讨论了PAI当前面临的挑战和局限性,以及有助于克服这些局限性的方法。最后,我们向读者概述了PAI成像微循环领域的未来趋势。
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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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