Impaired biliary excretion of organic anions and cations in bile duct-ligated rat

Abstract

The effects of bile duct ligation for 3 days on biliary excretion of organic anions and cations were studied in the rat. Biliary excretion of organic anions, sulfobromophthalein, leukotriene C₄ and pravastatin, was markedly impaired. Biliary excretion of organic cations, vinblastine and erythromycin was also markedly impaired. These findings indicate that, in the bile duct-ligated rats, various excretory pathways from the liver are damaged, at least partly due to the impairment of canalicular carriers.