Effect of Glytan on the Expression of the Nicotinic Acetylcholine Receptor a7 in Portal Hypertensive Rats

World Science and Technology Pub Date : 2010-06-01 DOI:10.1016/S1876-3553(11)60018-5

Jiang Junjie, Du Qinghong, Han Lin, Arezou Mashoufi, Li Pengtao

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引用次数: 1

Abstract

This study aimed to observe the expression of the nicotinic acetylcholine receptor nAchRa7 in liver tissue after portal hypertension (PHT). In the study, 40 male Sprague-Dawley rats, with weights between 240 g and 260 g, were randomly divided into sham-operated group, model group, and Glytan group according to their weights. Each group was observed at two time points, namely, two and four weeks after PHT. Common bile duct ligation was carried out on rats to induce PHT. The portal pressure of each group was measured, and the expression of nAchR a7 in the liver was detected by Western blotting at each time point. Results showed that the portal pressure and the expression of nAchRa7 in the model group increased significantly at two and four weeks after PHT. The portal pressure of the Glytan group was decreased compared to the model group, especially at four weeks after PHT. The expression of nAchRa7 in the liver of the Glytan group decreased significantly at four weeks after PHT. It is concluded that the change of portal pressure and the expression of nAchRa7 in the model and Glytan groups is consistent with the time sequence. Glytan may downregulate the portal pressure by affecting the nAchRa7 level in the liver.

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甘氨酸对门脉高压大鼠烟碱乙酰胆碱受体a7表达的影响

本研究旨在观察烟碱乙酰胆碱受体nAchRa7在门静脉高压症(PHT)后肝组织中的表达。选取体重240 ~ 260 g的雄性Sprague-Dawley大鼠40只，按体重随机分为假手术组、模型组和Glytan组。各组分别于PHT后2周和4周两个时间点进行观察。采用大鼠胆总管结扎术诱导PHT。测定各组门静脉压力，Western blotting检测各时间点肝脏nAchR a7的表达。结果显示，在PHT后2周和4周，模型组门静脉压力和nAchRa7的表达均显著升高。与模型组相比，甘坦组门静脉压力明显降低，尤其是在PHT后4周。在PHT后4周，Glytan组肝脏中nAchRa7的表达明显降低。由此可见，模型组和Glytan组门静脉压力的变化和nAchRa7的表达与时间序列一致。Glytan可能通过影响肝脏中nAchRa7水平下调门静脉压力。

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World Science and Technology

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