{"title":"The evaluation of diagnostic tests for determining the Toxoplasma gondii antibody status of organ transplant donors and recipients","authors":"G. Hodges , J.J. Gray , A.H. Balfour , T.G. Wreghitt","doi":"10.1016/S0888-0786(96)80016-3","DOIUrl":null,"url":null,"abstract":"<div><p>Ten commercially available assays (two passive latex agglutination assays, seven ELISAs and an immuno-blot filtration assay) for detecting <em>Toxoplasma gondii</em>-specific antibodies were evaluated using 168 serum samples from organ donors and transplant recipients. Results were compared with the ‘gold standard’ Sabin-Feldman dye test to give values for sensitivity and specificity for each kit. These ranged from 86.0% to 97.4% for sensitivity and from 93.6% to 100% for specificity. From these results recommendations for a kit of choice for testing organ donors and transplant recipients were formulated.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"8 1","pages":"Pages 13-17"},"PeriodicalIF":0.0000,"publicationDate":"1996-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0888-0786(96)80016-3","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Serodiagnosis and Immunotherapy in Infectious Disease","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0888078696800163","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Ten commercially available assays (two passive latex agglutination assays, seven ELISAs and an immuno-blot filtration assay) for detecting Toxoplasma gondii-specific antibodies were evaluated using 168 serum samples from organ donors and transplant recipients. Results were compared with the ‘gold standard’ Sabin-Feldman dye test to give values for sensitivity and specificity for each kit. These ranged from 86.0% to 97.4% for sensitivity and from 93.6% to 100% for specificity. From these results recommendations for a kit of choice for testing organ donors and transplant recipients were formulated.
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