{"title":"Effect of vitamin A on the activity of arylsulfatase and β-glucuronidase of rat tissues","authors":"Lichu Hsu , A.L. Tappel","doi":"10.1016/0926-6534(65)90036-9","DOIUrl":null,"url":null,"abstract":"<div><p>Vitamin A alcohol activates arylsulfatase (aryl-sulfatesulfohydrolase, EC 3-1.6.1) and inhibits β-glucuronidase (β-<span>d</span>-glucuronide glucuronohydrolase, EC 3.2.1.31) of rat colon. These effects were less pronounced with vitamin A acetate and they were negligible with vitamin A acid and other chemically related compounds. Action of vitamin A alcohol was not dependent upon the integrity of a particulate membrane and was unaffected by removal of lipid from the enzyme suspension, suggesting a direct effect on the enzyme proteins. Kinetics of arylsulfatase and β-glucuronidase were altered in the presence of vitamin A alcohol. Solubilized arylsulfatase and β-glucuronidase of particulate fractions from rat small intestine, kidney and liver showed the same response to vitamin A as the colon enzymes.</p></div>","PeriodicalId":100163,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Mucoproteins and Mucopolysaccharides","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1965-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6534(65)90036-9","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Mucoproteins and Mucopolysaccharides","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926653465900369","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15
Abstract
Vitamin A alcohol activates arylsulfatase (aryl-sulfatesulfohydrolase, EC 3-1.6.1) and inhibits β-glucuronidase (β-d-glucuronide glucuronohydrolase, EC 3.2.1.31) of rat colon. These effects were less pronounced with vitamin A acetate and they were negligible with vitamin A acid and other chemically related compounds. Action of vitamin A alcohol was not dependent upon the integrity of a particulate membrane and was unaffected by removal of lipid from the enzyme suspension, suggesting a direct effect on the enzyme proteins. Kinetics of arylsulfatase and β-glucuronidase were altered in the presence of vitamin A alcohol. Solubilized arylsulfatase and β-glucuronidase of particulate fractions from rat small intestine, kidney and liver showed the same response to vitamin A as the colon enzymes.
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