Chromatography of alkylating agents

Abstract

We have focused on the major areas of varied chromatographic procedures for the analyses primarily of a broad spectrum of alkylating agents (e.g., nitrosamines, epoxides, lactones, methanesulfonates, and miscellaneous agents such as nitrosoureas, urethanes and guanidines, as well as pyrrolizidine alkaloids). A similar treatment was extended to related but non-alkylating agents such as long-chain lactones and pesticidal epoxides. Particular stress was placed on the salient role of chromatographic procedures in the elaboration of compound homogeneity, metabolism, degradation and mode of action of these agents, with particular relevance to the environmental aspects.