Abdolraouf Samadi-Maybodi, Javad Abbasifar, Mohammad Malekaneh
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引用次数: 1
Abstract
In this study, molecularly imprinted Mn-doped ZnS quantum dots were used as nanosensors to determine diazepam and its metabolites. Mn-doped ZnS quantum dots (QDs) capped with L-cysteine were prepared using a sodium thiosulfate precursor and characterized by various methods. Methacrylic acid was used as a precursor for the synthesis of MIP Mn-doped ZnS QDs and then used to measure diazepam in various samples. The linear dynamic range, coefficient of determination, and detection limit were found to be 0.3 - 250 µmol/L, 0.989 and 8.78 × 10-2 µmol/L, respectively. The interference studies showed that the prepared nanosensor was selective for diazepam and its metabolites.
期刊介绍：
The Iranian Journal of Pharmaceutical Research (IJPR) is a peer-reviewed multi-disciplinary pharmaceutical publication, scheduled to appear quarterly and serve as a means for scientific information exchange in the international pharmaceutical forum. Specific scientific topics of interest to the journal include, but are not limited to: pharmaceutics, industrial pharmacy, pharmacognosy, toxicology, medicinal chemistry, novel analytical methods for drug characterization, computational and modeling approaches to drug design, bio-medical experience, clinical investigation, rational drug prescribing, pharmacoeconomics, biotechnology, nanotechnology, biopharmaceutics and physical pharmacy.
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