{"title":"The effect of α-mt on hyperthermia induced by chlorpromazine","authors":"W.J. Rewerski , W. Gumulka","doi":"10.1016/0028-3908(69)90026-4","DOIUrl":null,"url":null,"abstract":"<div><p>Administration of α-MT (four separate doses of 50 mg/kg with 4 hr interval between each injection) lowered the body temperature of rats. Hyperthermic effects induced by CPZ injection into the anterior part of hypothalamus persist in animals pretreated with α-MT. It is suggested therefore that the mechanism for the hyperthermic action of CPZ is more likely to be due to a direct effect of CPZ than with its interaction with NA.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1969-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90026-4","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900264","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
Administration of α-MT (four separate doses of 50 mg/kg with 4 hr interval between each injection) lowered the body temperature of rats. Hyperthermic effects induced by CPZ injection into the anterior part of hypothalamus persist in animals pretreated with α-MT. It is suggested therefore that the mechanism for the hyperthermic action of CPZ is more likely to be due to a direct effect of CPZ than with its interaction with NA.