Impact of formulation design and lyophilisation on the physicochemical characteristics of finasteride nanosystems.

IF 3 4区医学 Q2 CHEMISTRY, APPLIED Journal of microencapsulation Pub Date : 2023-03-01 DOI:10.1080/02652048.2023.2178537

Malik Muhammad Irfan, Shefaat Ullah Shah, Kifayat Ullah Shah, Nicolas Anton, Idoux-Gillet Ysia, Guillaume Conzatti, Kifayat Ullah Shah, Perennes Elise, Thierry Vandamme

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Abstract

The fundamental purpose of this study was to develop a stable lyophilised finasteride nanosystem (FNS-NS) for topical delivery. The FNS-NS was fabricated using an ultrasonication technique. The impact of two different cryoprotectants on the physicochemical characteristics of FNS-NS before and after lyophilisation was thoroughly investigated. The lyophilised FNS-NS had spherical shape with particle size lied between 188.6 nm ± 4.4 and 298.7 nm ± 4.7, low PDI values (0.26 ± 0.02 to 0.32 ± 0.02) and zeta potential ranging from -38.3 to +53.3 mV. The confocal laser microscopy depicted a comparatively higher cellular internalisation achieved for undecorated FNS-NS with respect to its chitosan-decorated counterpart. The lyophilised FNS-NS was stable for 90 days at proper storage conditions. The FNS-NS with 15% trehalose had appropriate physicochemical attributes that could be a promising carrier for topical delivery to treat androgenic alopecia.

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配方设计和冻干对非那雄胺纳米系统理化特性的影响。

本研究的基本目的是开发一种稳定的冻干非那雄胺纳米系统(FNS-NS)用于局部给药。利用超声技术制备了FNS-NS。研究了两种不同的冷冻保护剂对FNS-NS冻干前后理化特性的影响。冻干后的FNS-NS呈球形，粒径在188.6 nm±4.4 ~ 298.7 nm±4.7之间，PDI值较低(0.26±0.02 ~ 0.32±0.02)，zeta电位在-38.3 ~ +53.3 mV之间。共聚焦激光显微镜描绘了相对较高的细胞内化实现了未修饰的FNS-NS相对于其壳聚糖修饰的对应物。冻干后的FNS-NS在适当的保存条件下可稳定保存90天。添加15%海藻糖的FNS-NS具有良好的理化特性，是治疗雄激素性脱发的理想载体。

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.